Background: Coula edulis Bail (Olacaceae), is an evergreen tree growing to a height of 25-38 m. This study aimed at evaluating the antidermatophytic and toxicological properties of the stem bark of C. edulis extract as well as fractions and compounds isolated from it. Methods: The plant extract was prepared by maceration in CH2Cl2-MeOH (1:1 v/v). The fractionation of this extract was do...

Background and objectives:Wild Sage(Salvia macrosiphon Boiss.) known as “Marvak” in Persian is one of the polymorphic and abundant plants of Lamiaceae. The plants whole seeds usually soaked or boiled in hot water are widely used for inflammatory ailments in folk medicine. Documents have shown that there is scant information on the chemical constituents of this...

Abstract: Background: A daunting public health issue that mainly affects women is breast cancer. Resistance to drugs applied in the treatment of this cancer as well their side effects have made it necessary look for new therapeutic agents. Objectives: The study aimed at identification multi-targeted inhibitors molecular targets associated with Methods: We investigated fifteen compounds from Ber...

Background: Cancer is one of the biggest health problems worldwide, with lung cancer as first rank in number new cases and deaths. Non-small cell carcinoma (NSCLC) a type that accounts for about 85% all cases. Previous research identified role epidermal growth factor receptor (EGFR) most suitable target to treat NSCLC. This study aims identify potential compounds derived from mangrove plants ag...

Four phytoecdysteroids: (20-hydroxyecdysone-20, 22-monacetonide (1), 20-hydroxyecdysone (2), stigmasterol (3), gamma-sitosterol (4), were investigated for toxic effect against 3 rd /4 th instar larvae of Anopheles gambiae under laboratory conditions as individual compounds and in blends. The test larvae were treated with solutions containing the phytoecdysteroids of concentrations 1, 5 and 10pp...

Alcohols and hydrogen peroxide altered the permeability of membranes of Beta vulgaris root cells. Generally alcohols increased the permeability of membranes without going through an induction period except methanol which required a 10- to 15-hour induction period. The membrane effect of methanol could be inhibited with CaCl(2), cholesterol, beta-sitosterol, and stigmasterol. Cholesterol was the...

In this research work, a detailed phytochemical and biological investigation of Aconitum heterophyllum was accomplished. The cold methanolic root extract A. subjected to VLC for fractionation over silica gel, which led the isolation two compounds 1,1,8,8-trimethyl-4-methylene-decahydro- 1H-cyclopenta-[8]-annulen-1-ol (1) β-stigmasterol (2). were characterized by analysis their 1D 2D NMR spectra...