A first report on the fabrication of nanocomposite scaffolds containing nano-hydroxyapatite/carboxymethyl chitosan/β-cyclodextrin heterojunctions fused with date seed extract for bone tissue engineering applications.

The objectives of this study were to characterize a synthesis brom-isoflavanone (notated IF) with possible pharmacological activities, water insoluble and to examine the potential of beta-cyclodextrin to improve this property and obtain inclusion compounds that were analysed by different techniques: UV-Vis, IR, 1HNMR spectroscopy, thermal analysis. The presence of β-cyclodextrin rises the conte...

Batch synthesis of sulphobutyl ether β-cyclodextrin (also known as SBE-β-CD or SBECD) is a process effectively divided into three main stages, i.e. initial reagent dissolution, a sulphoalkylation reaction and final reaction quenching. This reaction is followed by downstream processing and purification, and ultimate isolation of the solid SBECD material. However, a feature associated with using ...

In the present work, we tried to identify mechanism why by which steroid alcohols accumulated when hydroxypropyl-β-cyclodextrin (HP-β-CD) was enhance sterol conversion rate. Compared with bioconversion system without HP-β-CD, reaction rate greatly improved in presence of but largely concurrently. a an enhanced rate, higher intracellular NADH/NAD+ level detected, and production increased also. M...

The current study was designed to develop a topical gel formulation for improved skin penetration of lornoxicam (LOR) for enhancement of its analgesic activity. Moreover, the effect of different penetration enhancers on LOR was studied. The LOR gel formulations were prepared by using hydroxylpropyl methylcellulose (HPMC) and carbopol. The carbopol gels in presence of propylene glycol (PG) and e...

Bacillus strains JCM 19045, JCM 19046, and JCM 19047 are alkaliphiles that produce β-cyclodextrin from starch. They are related to Bacillus xiaoxiensis and Bacillus lehensis. The genome information for these three strains will be useful for studies of the physiological role of cyclodextrin and cyclodextrin production.

In this article we investigate the effect of multivalency in chiral recognition. To this end, we measured the host-guest interaction of a β-cyclodextrin dimer with divalent chiral guests. We report the synthesis of carbohydrate-based water soluble chiral guests functionalized with two borneol, menthol, or isopinocampheol units in either (+) or (-) configuration. We determined the interaction of...

Meclizine HCl is a poorly water-soluble drug having a very slow-onset of action. The effect of 2-hydroxypropyl-β-cyclodextrins and β-cyclodextrins on its aqueous solubility and dissolution rate was investigated. The phase solubility profile indicated that the solubility of Meclizine HCl was significantly increased in the presence of both 2-hydroxypropyl-β-cyclodextrin and β- cyclodextrin; an ex...