OBJECTIVES Single nucleotide polymorphism (SNP) with a mutation can be used to identify the presence of the paternally-inherited wild-type or mutant allele as result of the inheritance of either allele in the fetus and allows the prediction of the fetal genotype. This study aims to identify paternal SNPs located at the flanking regions upstream or downstream from the β-globin gene mutations at ...

BACKGROUND The prevalence of postoperative cognitive disturbance, coupled with growing in vitro, cell, and animal evidence suggesting anesthetic effects on neurodegeneration, calls for additional study of the interaction between surgical care and Alzheimer neuropathology. The authors studied human cerebrospinal fluid (CSF) biomarkers during surgery. METHODS Eleven patients undergoing idiopath...

This paper proposes a test of the rank of the sub-matrix of β, where β is a cointegrating matrix. In addition, the sub-matrix of β⊥, an orthogonal complement to β, is investigated. We show that information on the rank of the sub-matrix of β and/or β⊥ is useful in several situations. We construct the test statistic by using the eigenvalues of the quadratic form of the sub-matrix. We show that th...

introduction the compounds known as β-adrenergic agonists (β-aa) are organic molecules that have the ability to bind to β-adrenergic receptors (β-ar) and start biochemical reactions that will result in increase of accretion of skeletal muscle and reduction in accretion of fat. the anabolic responses to β-aa are temporary, with a peak time occurring during the first 14 days, after which there is...