background: β-thalassemia is an autosomal hemoglobinopathy with inconsistent universal distribution. among patients with thalassemia diverse non-siderotic complications distinctly influence the attribute of life, including zinc deficiency due to varied etiologies. the objective of the present study was to determine zinc levels in patients with β-thalassemia major and its correlation with matern...

hemoglobin f (hbf, α 2 γ 2 ) is a major contributor to the clinical heterogeneity and ameliorating agent observed in patients with the β-globin disorders including β-thalassemia and sickle cell disease (scd). during fetal life, hbf is the major hemoglobin but is largely substituted by adult hemoglobin (hba, α 2 β 2 ) following a globin expression switch after birth. increased γ-globin expressio...

background: in the previous study, we have shown that the presence of a allele at position -588 in aγ-globin gene was highly frequent and closely associated with fetal hemoglobin elevation among β-thalassemia intermedia patients. therefore, we decided to investigate whether this allele (a allele at -588) could result in an increase in aγ-globin gene expression to ameliorate the severity of the ...

background: efficient induction of fetal hemoglobin (hbf) is considered as an effective therapeutic approach in beta thalassemia. hbf inducer agents can induce the expression of γ-globin gene and produce high levels of hbf via different epigenetic and molecular mechanisms. thalidomide and sodium butyrate are known as hbf inducer drugs. material and methods : cd133 + stem cells were isolated fro...

Trifluoromethylated organic compounds, especially chiral quaternary alcohols bearing trifluoromethyl group are of important intermediates in drugs, agrochemicals and etc.An efficient epoxidation of β-CF3-β,β-disubstituted unsaturated ketones (6) has been developed with environmental benign hydrogen peroxide as the oxidant and F5-substituted chiral qua...

Alkylpalladium complexes are important intermediates in several industrially relevant catalytic reactions, such as the Mizoroki–Heck reaction, alkyl C–H activation and ethylene polymerization. β-elimination—of either a hydride (β-Η) or heteroatom (β-Χ)—is most common decomposition pathway for these intermediates; this can lead to desired it hinder reaction progress, and/or vinyl halide co-polym...

Cinnamomum longepaniculatum essential oil (CLEO) possesses antibacterial, anti-inflammatory, and antioxidant activities. However, CLEO shows volatilization poor solubility, which limits its application field. In this research, inclusion complexes of β-cyclodextrin (β-CD) with were produced, physicochemical properties characterized. Response surface methodology was used to obtain optimum prepara...

In this study, β-cyclodextrin(β-CD) supported, hydroxyapatite encapsulated γ-Fe2O3 (γ-Fe2O3@HAp@β-CD) was successfully prepared and evaluated as a solid-liquid phase transfer catalyst and also a molecular host system and nanoreactor for the nucleophilic ring-opening of epoxides in water for the preparation of β-azido alcohols, β-nitro alcohols, an...

Chi Weigela, thuộc họ Kim ngân (Caprifoliaceae) được sử dụng rộng rãi trong y học cổ truyền tại các nước châu Á. Các hợp chất saponin phân lập từ chi Weigela có nhiều hoạt tính sinh mạnh như kháng oxy hóa, viêm và ung thư. Nghiên cứu đã tạo cao chiết ethanol loài florida “Jean’s Gold” bằng phương pháp xuất hỗ trợ vi sóng. Hai tách dựa trên sắc ký hiện đại. Cấu trúc hóa của này xác định là olean...