نتایج جستجو برای: α1 receptor
تعداد نتایج: 594913 فیلتر نتایج به سال:
As a central integrator of basal ganglia function, the external segment of the globus pallidus (GP) plays a critical role in the control of voluntary movement. The GP is composed of a network of inhibitory GABA-containing projection neurons which receive GABAergic input from axons of the striatum (Str) and local collaterals of GP neurons. Here, using electrophysiological techniques and immunofl...
Norepinephrine (NE) is a potent modulator of breathing that can increase/decrease respiratory activity by α1-/α2-adrenergic receptor (AR) activation, respectively. The retrotrapezoid nucleus (RTN) is known to contribute to central chemoreception, inspiration, and active expiration. Here we investigate the sources of catecholaminergic inputs to the RTN and identify respiratory effects produced b...
www.thelancet.com Published online May 28, 2015 http://dx.doi.org/10.1016/S0140-6736(15)60036-8 1 α1 antitrypsin is a serine antiprotease secreted by the liver. Its main function is inhibition of neutrophil elastase, a non-specifi c protease released by activated or dying neutrophils. In individuals with healthy concentrations of α1 antitrypsin, the fragile alveolar structures of the lung paren...
Ca2+ channels are voltage-gated ion present in the membrane of most excitable cells. The nomenclature for Ca2+channels was proposed by [127] and approved NC-IUPHAR Subcommittee on [70]. Most form hetero-oligomeric complexes. α1 subunit is pore-forming provides binding site(s) practically all agonists antagonists. 10 cloned α1-subunits can be grouped into three families: (1) high-voltage activat...
and Applied Analysis 3 2. Main Result Our main theorem is given by the following. Theorem 2.1. Let λ0 > 0, 0 < a ≤ 1 max{α1, α2} , |b 1| ≤ 2 α1 α2 , 0 ≤ a − b − 1 ≤ 1 max{α1, α2} . 2.1 If p ∈ P satisfies −2 2 < arg ( λ0 ( p z )a zp′ z ( p z )b ) < γ1π 2 z ∈ U , 2.2 where γj γj a, b, α1, α2 aαj 2 π tan−1 ( α1 α2 /2 cos ( βπ/2 ) cos ( a − b − 1 αjπ/2 ) 2λ0δj a, b, α1, α2 α1 α2 /2 cos ( βπ/2 ) sin...
BACKGROUND Agonistic autoantibodies directed at the alpha(1)-adrenergic receptor (alpha(1)-AAB) have been described in patients with hypertension. We implied earlier that alpha(1)-AAB might have a mechanistic role and could represent a therapeutic target. METHODOLOGY/PRINCIPAL FINDINGS To pursue the issue, we performed clinical and basic studies. We observed that 41 of 81 patients with refrac...
UNLABELLED γ-aminobutyric acid (GABA)-A receptor-mediated neural transmission is important to promote practice-dependent plasticity after brain injury. This study investigated alterations in GABA-A receptor binding and functional and anatomic connectivity within the motor cortex in children with cerebral palsy (CP). METHODS We conducted (18)F-fluoroflumazenil PET on children with hemiplegic C...
BACKGROUND & OBJECTIVES Observation of an increased frequency of an intermediate deficiency of serum alpha1-antitrypsin (α1-AT) in patients with Tropical Pulmonary Eosinophilia (TPE) was earlier reported. Though the possibility of existence of an acquired deficiency was suggested, without phenotyping a hereditary α1-AT deficiency in TPE could not totally be ruled out. In this study, we have don...
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