Alpha-lipoic acid is a naturally occurring substance, essential for the function of different enzymes that take part in mitochondria's oxidative metabolism. It is believed that alpha-lipoic acid or its reduced form, dihydrolipoic acid have many biochemical functions acting as biological antioxidants, as metal chelators, reducers of the oxidized forms of other antioxidant agents such as vitamin ...

Introduction: Diabetic complications as peripheral neuropathy and delayed wound healing affect patient’s quality of life may lead to amputation. Several mechanisms are involved in mediating these including accumulation Advanced Glycation End Products (AGEs) the subsequent state inflammation which were investigated current study. Methos: A fixed size was induced STZ-diabetic rats effect diabetes...

Peritoneal contamination is considered to be risk for anastomosis. In our study, the effect of vitamin C and lipoic acid combination on anastomosis healing following colonic anastomosis performed in rats with experimentally-induced intraabdominal sepsis has been investigated. The rats in the control group were given only routine enteral feed in the preoperative and postoperative periods. The ra...

Methylglyoxal (MG), a reactive dicarbonyl compound, is a metabolic byproduct of glycolysis often found at high levels in blood from diabetic patients. The effect of lipoic acid on MG-induced oxidative stress was investigated using LLC-PK 1 renal tubular epithelial cells, which are susceptible to oxidative stress. MG (500 M ) treatment induced LLC-PK 1 cell death to nearly 50% compared with non-...

Objective. This study aims to evaluate whether alpha-lipoic acid and/or coenzyme Q10 can protect the prepubertal ovarian tissue from ischemia-reperfusion injury in an experimental rat model of ovarian torsion. Materials and Methods. Forty-two female preadolescent Wistar-Albino rats were divided into 6 equal groups randomly. The sham group had laparotomy without torsion; the other groups had tor...