objective: although sodium valproate came to the market as an anticonvulsant drug, nowadays it's wildly used in the management of psychiatric disorders. it is used as a mood stabilizer and as an adjunctive agent in treatment of depression and psychosis. there are controversies regarding sodium valproate efficacy in psychosis. although some studies have reported that it is effective in the ...

Background and objective: According to the diathesis-stress model, disturbances of hypothalamic-pituitary-adrenal (HPA) axis are thought play a role in development, onset, progression psychosis. The aim this paper is present available body evidence on abnormalities cortisol awakening response (CAR) psychotic disorders at-risk states. Methods: Review literature from years 2011-2022 across three ...

Advocates of early intervention in psychosis choose to treat the association between long duration of untreated psychosis (DUP) and poor outcome as evidence that reducing DUP will improve outcomes. I question this view and argue that DUP does not predict outcome but rather that mode of onset of psychosis predicts DUP and outcome.

“Breakthrough” of psychosis despite good compliance antipsychotics medication for a long time is major obstacle to the treatment schizophrenia, whether mechanism caused by dopamine hypersensitivity or insufficient dose antipsychotics. Researchers advocating “Dopamine Supersensitivity Psychosis” (DSP) emphasize avoid excessive inhibition 2 receptors from beginning treatment. On other hand, resea...

Abstract Background: Lycanthropy is an unusual belief or delusion in which the patient thinks that he/she has been transformed into an animal. In rare cases, the patient believes that another person has been transformed into an animal. Case Report: We report a patient with an uncommon variant of lycanthropy is introduced. The symptoms appeared after consumption of ecstasy. This show...

Prospective evaluation of youths with early psychotic-like experiences can enrich our knowledge of clinical, biobehavioral and environmental risk and protective factors associated with the development of psychotic disorders. We aimed to investigate the predictors of persistence or worsening of psychosis spectrum features among US youth through the first large systematic study to evaluate subcli...

OBJECTIVE Failing of mentalising has been suggested to underlie certain symptoms of psychosis. An as yet unresolved issue is whether mentalising deficits reflect a characteristic which can also be detected in people at risk for psychosis or people with evidence of subclinical expression of psychosis. This study wanted to assess an aspect of mentalising in four groups with different levels of ps...

This study examined the hypothesis that developmental expression of psychometric risk in the form of subclinical psychotic experiences in the general population is usually transitory but in some instances may become abnormally persistent and progress to a clinical psychotic state. A prospective cohort study was conducted in a general population sample of 845 adolescents, aged 14-17 years, in Mu...

We present the case of a 45-year-old female patient who developed an acute polymorphic psychosis after treatment with the antibiotic ciprofloxacin. The patient showed a distinct neuropsychological deficit of the executive function. Comparing the psychopharmacological features of ketamine and ciprofloxacine we hypothesize that ciprofloxacine leads to psychosis similar to a ketamine induced psych...

Synthetic cannabinoids- (SCs-) induced psychosis is a growing public health concern. It leads to significant impairment, including emotional distress, difficulty communicating, and other debilitating symptoms. In this case report, we discuss a patient with no previous history of psychotic symptoms, presenting with first-episode psychosis in the context of progressive, acutely worsening, disorga...