The efficacy of present day antineoplastic regimens depends upon the delivery and penetration of therapeutic agents through the tumor vas cular and interstitial spaces to the tumor cell target. The distribution of relevant molecules or cells in a solid tumor is often poor and heteroge neous and is believed to be due to a number of pathophysiological factors, including elevated interstitial flui...

Vincristine (VCR) has been shown to enhance the trans port of methotrexate (MTX) in animal systems and in acute myelogenous leukemia cells in vitro. In this report, the uptake of MTX and the effect of VCR were studied in two human lymphoblastoid cell lines grown in tissue culture. The effect of VCR on MTX suppression of deoxyuridine incorporation into DNA by these cell lines was also investi ga...

Aims—To investigate whether anomalies of transforming growth factor â type II receptor (TGF-â RII) expression occur in the early stages of laryngeal carcinogenesis and to assess their importance in the development of laryngeal squamous cell carcinoma. TGF-â RII status was examined in laryngeal premalignant lesions coupled with malignant evolution and compared with a control group of similar les...

The asymmetric nature of the boson ‘destruction’ operator â and its ‘creation’ partner ↠is made apparent by applying them to a quantum state |ψ〉 different from the Fock state |n〉. We show that it is possible to increase (by many times or by any quantity) the mean number of quanta in the new ‘photonsubtracted’ state â|ψ〉. Moreover, for certain ‘hyper-Poissonian’ states |ψ〉 the mean number of q...

â â â â â  abstract: â  as the number of independent countries increases and their economies become more integrated, we would expect to observe more multi-country currency ::::union::::s. this paper explores the pros and cons for different countries to adopt as an anchor the us dollar, the euro or the yen. in addition, it addresses the question of how co-movement of outputs and prices would res...

â â  this study, which is done in the light of modern research, is a small step in exploring the great heritage of arabic rhetoric. it may be quite appropriate to explore rhetorical techniques in the work of 'abd al- qähä«r al-jurjänä«, particularly because he has been neglected in many pieces of research on rhetoric. this article is an attempt for describing 'abd al- qähä«r’s ap...

â Novel method creates cases independent of the knowledge acquisition process â Such a creative approach is not doomed to reimplement incorrect knowledge possibly contained in the knowledge base, but may detect it â The morphing method is not performed as a single run but is an iterative process in order to achieve a sufficient test case coverage â Evaluation with medical consultation system: s...

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