The severe acute respiratory syndrome (SARS) epidemic was characterized by high mortality rates in the elderly. The molecular mechanisms that govern enhanced susceptibility of elderly populations are not known, and robust animal models are needed that recapitulate the increased pathogenic phenotype noted with increasing age. Using synthetic biology and reverse genetics, we describe the construc...

Transboundary zoonotic diseases, several of which are vector borne, can maintain a dynamic focus and have pathogens circulating in geographic regions encircling multiple geopolitical boundaries. Global change is intensifying transboundary problems, including the spatial variation of the risk and incidence of zoonotic diseases. The complexity of these challenges can be greater in areas where riv...

JAVMA, Vol 233, No. 10, November 15, 2008 A human and animal populations increase, the need for veterinarians to serve as leaders in the prevention of and response to zoonotic diseases has never been greater. Zoonoses are defined as diseases that may be directly or indirectly transmitted from wild or domestic animals to humans. Of the 1,461 diseases now recognized in humans, approximately 60% a...

AIM The present study was undertaken to understand the zoonotic importance of canine scabies and dermatophytosis with special reference to the knowledge level of dog owners in urban areas of Gujarat. MATERIALS AND METHODS The study was carried out in randomly selected 120 dog owners of 3 urban cities (viz., Ahmedabad, Anand and Vadodara) of Gujarat state, India. Dog owners (i.e., respondents)...

As meat consumption is increasing worldwide to cover for protein demands, also raise concerns and challenges regarding meat hygiene and safety. The current one year follow up study aimed at investigating on sanitary practices and occurrence of zoonotic conditions, during post-mortem examination, in cattle at slaughter in Morogoro Municipality abattoir. Sanitary practices were assessed through d...

BACKGROUND Hemophagocytic lymphohistiocytosis (HLH) is a rare syndrome that is often fatal despite treatment. It is caused by a dysregulation in natural killer T-cell function, resulting in activation and proliferation of histiocytes with uncontrolled hemophagocytosis and cytokines overproduction. The syndrome is characterized by fever, hepatosplenomegaly, cytopenias, liver dysfunction, and hyp...

OBJECTIVE To identify emerging animal and zoonotic diseases and associated geographic distribution, disease agents, animal hosts, and seasonality of reporting in the Program for Monitoring Emerging Diseases (ProMED)-mail electronic early warning system. DESIGN Retrospective study. SAMPLE POPULATION 10,490 disease reports. PROCEDURES Descriptive statistics were collated for all animal dise...

BACKGROUND Many factors have been mentioned as contributing to under-diagnosis and under-reporting of zoonotic diseases particularly in the sub-Sahara African region. These include poor disease surveillance coverage, poor diagnostic capacity, the geographical distribution of those most affected and lack of clear strategies to address the plight of zoonotic diseases. The current study investigat...