Mutations in the metalloprotein Cu,Zn-superoxide dismutase (SOD1) cause approximately 20% of familial cases of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease for which effective therapeutics do not yet exist. Transgenic rodent models based on over-expression of mutant SOD1 have been developed and these have provided opportunity to test new therapeutic strategies and to s...

Combined coordination of Zn(II) and Cu(I) or Cu(II) to the amyloid-β peptide has been investigated using XANES, EPR and NMR spectroscopies. While Zn(II) does alter Cu(II) binding to Aβ, this has no effect on (Aβ)Cu induced ROS production and associated cell toxicity.

a greenhouse experiment was conducted using completely randomised design (factorial) with three replications to study the residual effect of organic manures (municipal solid waste compost and cow manure), zinc (0 and 50 kgha-1) and boron (0 and 10 kg.ha-1) by using znso4 and h3bo3 salts respectively, (applied earlier for millet (panicum italicum l.) crop) on soil properties and chemical composi...

1. Apo-superoxide dismutase was more labile toward a variety of inactivating stresses than was the holoenzyme. 2. cu++ restored catalytic activity to the apoenzyme and markedly enhanced its thermal stability but Cu++ plus Zn++ were needed to attain the stability of the native enzyme. 3. Co’-+ or Hgii were able to replace Zn++ in increasing the thermal stability of the Cu+f-repleted apoenzyme. I...

human activities have continuously increased the level of heavy metal ions circulating in the environment. it is important to understand the tolerance of plant species to high concentrations of heavy metals. very little is known on the response of eucalyptus species to zn and cu toxic concentrations eucalyptus camaldulensis, e. microtheca, and e. occidentalis seeds were grown in silt and irriga...

all aquatic organisms are directly or indirectly affected by the physical characteristics of their environment, especially the chemical composition of the water. the high concentration levels, damage tissues and interfere with the normal growth and proliferation. the aim of this research was to investigation acute toxicity of znso4 and cucl2 to gambusia holbrooki by static bioassays at differen...

In a 36-d experiment, 32 pigs were depleted of Zn (24 d) using a soy-isolate (basal) diet (17 mg/kg of Zn) and then fed the basal diet (12 d) supplemented with 45 mg/kg of Zn from ZnSO4 (purified zinc sulfate dry powder, ZnSO4.nH2O) or from a Zn amino acid chelate (ZnAAC) to study the effectiveness of these dietary Zn sources in restoring serum and soft tissue Zn concentrations. Concurrently, n...

A detailed study has been conducted to determine the contamination of Thohoyandou roadside soils, vegetation, sewage and river waters by Zn, Cu, Cr, Pb, Cd, Fe, Pt and Pd. The study further investigated the correlation between these trace metals in roadside soils and vegetation in order to infer the potential impacts of roadside trace metals contamination of vegetation. Collected surface soil a...

Bioaccumulation of Cu, Zn, Hg in muscles and liver tissues of stellate sturgeon (Acipenser stellatus) from the southern Caspian Sea was measured. Effects of condition factor (CF), age and hepatosomatic index (HSI) on metal accumulation were also determined. Some 40 stellate sturgeons were collected using gill nets in winter and spring 2007-2008 from the southern shores of the Caspian S...