Sensitivity of GABAA receptors (GABARs) to inhibition by zinc and other divalent cations is influenced by the alpha subunit subtype composition of the receptor. For example, alpha6beta3gamma2L receptors are more sensitive to inhibition by zinc than alpha1beta3gamma2L receptors. We examined the role of a His residue located in the M2-M3 extracellular domain (rat alpha6 H273) in the enhanced zinc...

Information from animal studies has demonstrated the harmful effects of zinc supplementation on copper transport. Although some studies have been carried out in humans, the effect on humans has not been as well documented as the effect on animals. Forty-seven healthy volunteers (26 women and 21 men) took part in a double-blind cross-over trial which lasted for 12 weeks. The subjects were asked ...

Flotation is, doubtless, the most important process among the various techniques used for the treatment of ore. This generalpurpose technique allows the treatment of several complex ores (lead zinc, copper zinc), sulphides (copper, lead, and zinc), oxides (hematite, quartz), oxidized minerals (malachite, cerusite) and even non-metal ores (fluorite, phosphate, coal). Due to the flotation, it is ...

With the exception of calcium very little is known about metal binding characteristics of either human salivary or porcine pancreatic amylase. In order to learn more about these protein-metal binding interactions, calcium-free human salivary and porcine pancreatic amylase [P(protein)] were obtained by carboxymethylcellulose chromatography of the partially purified proteins. Because these protei...

To investigate the relationships of trace element concentrations vs hematopoiesis and iron parameters, we measured lead, copper, zinc, cadmium, and ferritin levels in 251 healthy adolescents. Concentrations of trace metals were determined by atomic absorption spectrophotometry. There were no significant gender-related differences in serum copper or serum cadmium concentrations. However, blood l...

OBJECTIVES To evaluate the correlations of the serum concentrations of copper, zinc, and manganese with lipid profile parameters of adult men in Mosul City, Iraq. METHODS The study included 51 apparently healthy adult men as a control group aged 34-62 years (group 1), and 31 hyperlipidemic patients aged 37-60 years (group 2). Trace elements copper, zinc and manganese were determined using ato...

INTRODUCTION Bariatric surgery leads to a significant body weigh reduction although it is associated to a higher risk of presenting some nutritional deficiencies. A common complication, little studied and mainly related to zinc deficiency is alopecia. OBJECTIVES To compare the nutritional status of zinc, iron, copper, selenium and protein-visceral in women with different degrees of hair loss ...

In this paper a biochemical hypothesis is proposed for the working of acupuncture. In this hypothesis, copper and zinc ions play an important role. Inserting a needle into an acupuncture point will locally damage the tissue. It is known that this causes a local release of zinc ions. It is also known that both zinc ions and copper ions bind on the intracellular transport protein metallothionein,...

Treatment with oral chelation therapy withD-penicillamine for copper accumulation inWilson disease was first developed in the 1950s, and preemptive treatment became the standard of care for patients.1 An alternative chelating agent, trientine, was developed more than a decade later and has gained more acceptance as first-line treatment due to its safety profile and demonstration of efficacy.2,3...

Glabrin (2-Piperidine, carboxylic acid, 4, 5, dihydroxy, -1-methyl) was isolated from Pongamia glabra seeds and metal complexes were prepared by refluxing with acetates of cupper, zinc and mercury, estimation was carried out by simple idometric method for copper complex and E.D.T.A. method for zinc and mercury complexes of glabrin. Results of present study reveal that the metal complexes show c...