Development of new treatments for drug addiction will depend on high-throughput screening in animal models. However, an addiction biomarker fit for rapid testing, and useful in both humans and animals, is not currently available. Economic models are promising candidates. They offer a structured quantitative approach to modeling behavior that is mathematically identical across species, and accru...

The continuum of smoking behavior among children and adolescents can be described in stages of preparation, trying, experimentation, regular smoking, and nicotine dependence or addiction. Persons who have smoked can discontinue at any stage, but quitting becomes more difficult as smokers progress through the continuum and become increasingly dependent on nicotine. Nicotine addiction is characte...

Drug addiction is a worldwide epidemic. To reduce its spread, understanding the nature of addiction is crucial and possible treatments have to be developed. Current models of drug addiction only explain why addiction is overwhelming and cannot be overcome. Instead we focus on the dynamic of addiction, which includes rehabilitation and relapse. The model identifies the combination of factors tha...

Liability to develop drug addiction is heritable, but the precise contribution of non-Mendelian factors is not well understood. Here we separate male rats into addiction-like and non-addiction-like groups, based on their incentive motivation to seek cocaine. We find that the high incentive responding of the F0 generation could be transmitted to F1 and F2 generations. Moreover, the inheritance o...

objective: to investigate relationship between addiction potentiality and different dimensions of emotional self-regulation. materials and methods: this descriptive and correlational study included students of sistan and baluchistan university, sistan and baluchestan, iran. participants were selected by random sampling method. we applied addiction potential scale (aps) and difficult in emotion ...

conclusions tattooing and longer duration of addiction were two important factors that significantly increased retention in the program. in contrast, history of using harm reduction services was the factor that decreased persistence. the risk of quitting the program may decrease about 68% in those who did not involve in harm reduction programs. patients and methods this cohort study analyzed da...

The purpose of this review is to discuss recent findings related to sex differences in behavioral dyscontrol that lead to drug addiction, and clinical implications for humans are discussed. This review includes research conducted in animals and humans that reveals fundamental aspects of behavioral dyscontrol. The importance of sex differences in aspects of behavioral dyscontrol, such as impulsi...