BACKGROUND Nail apparatus melanoma is known to be associated with a poor prognosis, mainly because of a delay in diagnosis that is made at an invasive stage. This delay is particularly true in cases involving amelanotic melanoma. To our knowledge, only 1 case of in situ amelanotic melanoma of the nail unit has previously been described. We report 3 cases of in situ amelanotic melanoma with clin...

Ingrown nails are defined as inflammation of the lateral nail fold that is caused by penetration by the nail plate and associates with pain and/or infection. The pain associated with ingrown nail hampers walking, raises the risk of falls, and decreases the quality of life. The Sogawa method is a novel conservative medical treatment for ingrown nails that is based on stainless steel wire. It was...

Brittle nail syndrome is a heterogeneous abnormality, characterized by increased fragility of the nail plate. Brittle nails affect about 20% of the population and women are affected twice as frequently as men. The vast majority of patients experience brittle nails as a significant cosmetic problem and a substantial number indicate that these nail abnormalities are painful, impair daily activiti...

Two siblings with congenital lymphedema had recurrent pleural effusions in adult life. The brother also had yellow toenails and thus represents an example of the syndrome of lymphedema, pleural effusions, and yellow nails. An immunologic deficiency state in these patients was suggested by recurrent bronchopthonary and skin infections, hypogammaglobulinemia, and episodes of lymphopenia. The sist...

Nail biopsy is a safe and useful technique for diagnosis and management of many nail conditions. A basic understanding of nail anatomy and biology is a prerequisite for a successful nail biopsy. The patient must be adequately prepared and there needs to be excellent anesthesia and hemostasis. The type of nail biopsy depends largely on the location of the pathology in the nail unit. The techniqu...

INTRODUCTION Chronic hemodialysis patients experience frequent and varied mucocutaneous manifestations in addition to hair and nail disorders. The aim of this study was to evaluate the prevalence of dermatological changes among patients with end-stage renal disease under hemodialysis in a hemodialysis unit in Tanta University hospitals over a period of 6 months, and to evaluate the relations of...

We hypothesised that Hansen Solubility Parameters (HSPs) can be used to predict drug-nail affinities. Our aims were to: (i) determine the HSPs (δD, δP, δH) of the nail plate, the hoof membrane (a model for the nail plate), and of the drugs terbinafine HCl, amorolfine HCl, ciclopirox olamine and efinaconazole, by measuring their swelling/solubility in organic liquids, (ii) predict nail-drug inte...