Kwashiorkor is a type of protein-energy malnutrition where diet protein deficit is found, in spite of appropriate caloric intake. Cutaneous manifestations include xerosis, with abnormally dry skin that has a flaking enamel paint aspect, a typical red to gray-white hair color, the "flag sign" and more evident edema in lower limbs and face, giving it a full moon appearance. This article reports a...

An increase in the expression of epidermal growth factor receptors (EGFR) is involved in the stimulation of tumor development. EGFR inhibitors have shown efficacy in the treatment of neoplasms of the head, neck, colon and lung. EGFR when inhibited can cause cutaneous reactions in more than 50% of the patients. They are usually reversible, but when severe, limit the use of the drug. Papulopustul...

A 12-year old boy presented with a 2 months history of an itchy eruption over the extremities. The patient complained of a cyclic course with exacerbation in winter. There was no history of asthma, rhinitis or atopic dermatitis. Examination revealed grouped follicular papules forming discoid patches (Fig 1) predominantly over the extensor aspect of forearms and legs. The papules were skin color...

Comparison of Skin Toxic Effects Associated With Gefitinib, Erlotinib, or Afatinib Treatment for Non–Small Cell Lung Cancer Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) have been widely used to treat non–small cell lung cancer. Four major skin toxic effects with different incidences have been reported from clinical studies, including acneiform eruption (60%-94%), prur...

A compromised skin barrier plays a major role in many dermatoses including irritant and allergic contact dermatitis, atopic dermatitis, dry skin, aged skin, xerosis, rosacea, and acne [1–5]. Many of these conditions share common defects in the skin barrier and an association with inflammation [4,6]. The knowledge we have regarding specific lipid deficiencies, pH aberration, inflammation, irregu...

We tested the carbon substrate assimilation patterns of 40 Corynebacterium amycolatum strains, 19 C. minutissimum strains, 50 C. striatum strains, and 1 C. xerosis strain with the Biotype 100 system (bioMérieux, Marcy-l'Etoile, France). Twelve carbon substrates of 99 allowed discrimination among the species tested. Additionally, assimilation of 3 of these 12 carbon substrates (maltose, N-acetyl...

Xerosis is a common skin condition as well key aspect of number diseases associated to hereditary and acquired conditions. The objective this study was formulate evaluate the pluronic lecithin organogel containing natural moisturizing agents for topical application. Different formulations organogels were prepared by using Pluronic F127, Lecithin, Vitamin E, Aloe vera, water, sorbic acid, potass...

Sorafenib (Nexavar®, BAY 43-9006) is a novel, orally administered multi-kinase inhibitor that has recently been approved for the treatment of metastatic renal cell carcinoma. It is also used to delay disease progression in patients with advanced solid organ malignancies and metastatic melanoma. Sorafenib is associated with a relatively high incidence of dermatologic adverse events. The commonly...

Sir, Down’s syndrome (trisomy 21) is a multisystem disorder with a birth incidence of approximately 1 in 700 live births, making it the most common autosomal chromosomal disorder causing mental retardation. Down’s Syndrome is also associated with an increased incidence of cutaneous disorders.[1-4] In particular, there seems to be an increased incidence of xerosis, atopic dermatitis, seborrheic ...