CD44 is a widely distributed cell surface glycoprotein whose principal ligand has been identified as hyaluronic acid (HA), a major component of the extracellular matrix (ECM). Recent studies have demonstrated that activation through CD44 leads to induction of effector function in T cells and macrophages. In the current study, we investigated whether HA or monoclonal antibodies (MoAbs) against C...

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The CD44-negative T lymphoma AKR1 (CD44.2 genotype) was transfected with a CD44.1 cDNA. The intact cDNA conferred on the transfected cells the ability to bind hyaluronic acid (HA) both from solution and immobilized on culture plates. It also conferred a CD44-dependent and hyaluronidase-sensitive increase in adhesion to a lymph node endothelial cell line. A mutant cDNA which codes for a CD44 mol...

A hallmark of the immune response to influenza is repeated encounters with proteins containing both genetically conserved and variable components. Therefore, the B and T cell repertoire is continually being remodeled, with competition between memory and naïve lymphocytes. Our previous work using a mouse model of secondary heterosubtypic influenza infection has shown that this competition result...

A field experiment was conducted at the Agronomy Field Laboratory, Bangladesh Agricultural University, Mymensingh during the period from July to December 2011 to evaluate the effect of variety and placement method of urea super granule (USG) on the yield performance of T. aman rice varieties. The experiment consisted of three aman rice varieties viz., Pajam, BR11, BRRI dhan40 and four placement...

This study was carried out in 2004 in Iguacu National Park (INP), Paraná-Brazil. The vegetation is composed of Araucaria Forest (AF) (13.1%) and Seasonal Semi-deciduous Forest (FES) (86.9%). Two types of materials were analyzed: litter (L) and woody material (W) (alive (A) and dead (D)), and classified by diameter: W1(0–0.70 cm), W2(0.71–2.5 cm), W3(2.51–7.50 cm), and W4(≥7.5 cm). The results f...

Allogeneic bone marrow transplantation (BMT) is a common treatment of hematologic malignancies. Recurrence of the underlying malignancy is a major cause of treatment failure. Donor-derived cytotoxic T lymphocytes (CTLs) specific for patients' minor histocompatibility antigens (mHags) play an important role in both graft-versus-host disease (GVHD) and graft-versus-leukemia (GVL) reactivities. mH...

The induction of cellular acquired thermal tolerance (ATT) during heat acclimation (HA) in humans is not well described. This study determined whether exercise-HA modifies the human heat shock protein (HSP)72 and HSP90 responses and whether changes are correlated with physiological adaptations to HA. Using a 10-day HA protocol comprising daily exercise (treadmill walking) in a hot environment (...

to study the effects of integration of mechanical control with herbicides on yield and yield components of soybean (glycine max) a field experiment was conducted during 2003-2004 at the research farm of agronomy department, agriculture campus of tehran university, karaj. a randomized complete block design (rcbd) of 18 treatments was applied, each treatment being replicated 3 times. treatments i...

The effect of different systems of N fertilization on nitrogen balance and N transformation in the soil was studied in long-term stationary experiments (1991–2002) with successive growing of maize. Average dry matter yield for the control without fertilization in the period 1991–2002 was 11.67 t of dry matter per ha, which was by 2–2.9 t less than for fertilization treatments. Statistically sig...