T he diabetic foot syndrome represents a major problem in the health care of diabetic patients. Understanding the molecular basis of this disease is an important step toward a rational treatment. Due to the systemic character of diabetes, disturbances in several basic cell functions appear to contribute to impaired wound healing. Many essential processes of normal wound healing are regulated in...

The immediate effects depend on the size, shape, type, velocity and track of the missile. A high velocity rifle or machine-gun bullet entering the chest through an intercostal space and making its way out through a posterior space may occasion, apart from the initial shock, little disability and with luck no complications. A small more slowly moving vulnerant may produce a punctured wound such ...

OBJECTIVE To describe risks for, and microbiology and antimicrobial resistance patterns of, war trauma associated infections from Operation Iraqi Freedom. BACKGROUND : The invasion of Iraq resulted in casualties from high-velocity gunshot, shrapnel, and blunt trauma injuries as well as burns. Infectious complications of these unique war trauma injuries have not been described since the 1970s....

OBJECTIVE Studies in other surgical specialties have suggested that pre-emptive wound infiltration using a local anesthetic may reduce post-operative pain. We report the first randomized trial to assess the use of pre-emptive local anesthesia in video-assisted thoracic surgery (VATS). METHOD Thirty-one consecutive patients undergoing bilateral needlescopic VATS sympathectomy for palmar hyperh...

Deep sternal wound infection is a severe complication after open heart surgery. According to the different severity and dimensions of the deep sternal wound infection, the treatment method is different. In this study, we aimed to describe our experience with the rectus abdominis myocutaneous flap for large sternal wound management, especially when 1 or 2 internal mammary arteries were absent.Be...

- healing of surgical wounds and their complications such as infection or scar formation are of major concern in surgery. tissue glues are advanced to reduce these problems. in a prospective study, we have evaluated surgical wound healing in 76 patients whose surgical wounds were repaired by tissue glues (histoacryl). this study was performed in four leaching hospitals (sina, shariaty, shohada,...

Aim: Patients with Ehlers-Danlos Syndrome (EDS) are considered to have an increased risk for wound healing complications. Surgeons may therefore be hesitant offer elective surgeries, including gender-affirming surgeries (GAS), EDS patients. At our center, we frequently encountered patients presenting GAS evaluation the co-existing diagnosis of EDS. This study aims establish prevalence in and co...

BACKGROUND Until now, several formulations of topical phenytoin have been used to promote wound healing. AIM This study was aimed at re-evaluating the effects of a newly formulated phenytoin mucoadhesive paste on wound healing after oral biopsy. SUBJECTS AND METHODS In a double-blind clinical trial, 35 consecutive patients with oral lichenoid or lichen planus lesions were randomized into tw...

The retrospective study recently published by Margolis et al. (1) raises many questions. First, it appears that the excluded cohort had a lower extremity amputation (LEA) rate of 4.5% in the first 28 days. This seems high. Previous studies have shown overall amputation rates (major and minor) after 1 year of 12.5–22.6% in two smaller cohort studies of sicker patients (2,3). Given that the exclu...