نتایج جستجو برای: wnt pathway

تعداد نتایج: 325509  

2018
Vitezslav Kriz Vladimir Korinek

In this review, we address aspects of Wnt, R-Spondin (RSPO) and Hippo signalling, in both healthy and transformed intestinal epithelium. In intestinal stem cells (ISCs), the Wnt pathway is essential for intestinal crypt formation and renewal, whereas RSPO-mediated signalling mainly affects ISC numbers. In human colorectal cancer (CRC), aberrant Wnt signalling is the driving mechanism initiating...

2017
Marcus M Fischer Belinda Cancilla V Pete Yeung Fiore Cattaruzza Cecile Chartier Christopher L Murriel Jennifer Cain Raymond Tam Chieh-Yang Cheng James W Evans Gilbert O'Young Xiaomei Song John Lewicki Ann M Kapoun Austin Gurney Wan-Ching Yen Timothy Hoey

The WNT pathway mediates intercellular signaling that regulates cell fate in both normal development and cancer. It is widely appreciated that the WNT pathway is frequently dysregulated in human cancers through a variety of genetic and epigenetic mechanisms. Targets in the WNT pathway are being extensively pursued for the development of new anticancer therapies, and we have advanced two WNT ant...

Journal: :Neuron 2015
Hyun Kyoung Lee Lesley S. Chaboub Wenyi Zhu Daniel Zollinger Matthew N. Rasband Stephen P.J. Fancy Benjamin Deneen

Wnt signaling plays an essential role in developmental and regenerative myelination of the CNS; however, contributions of proximal regulators of the Wnt receptor complex to these processes remain undefined. To identify components of the Wnt pathway that regulate these processes, we applied a multifaceted discovery platform and found that Daam2-PIP5K comprise a novel pathway regulating Wnt signa...

2012
Alfiya Akhmetshina Katrin Palumbo Clara Dees Christina Bergmann Paulius Venalis Pawel Zerr Angelika Horn Trayana Kireva Christian Beyer Jochen Zwerina Holm Schneider Anika Sadowski Marc-Oliver Riener Ormond A. MacDougald Oliver Distler Georg Schett Jörg H.W. Distler

The transforming growth factor-β (TGF-β) signalling pathway is a key mediator of fibroblast activation that drives the aberrant synthesis of extracellular matrix in fibrotic diseases. Here we demonstrate a novel link between transforming growth factor-β and the canonical Wnt pathway. TGF-β stimulates canonical Wnt signalling in a p38-dependent manner by decreasing the expression of the Wnt anta...

Journal: :Neuron 2006
Gary A. Wayman Soren Impey Daniel Marks Takeo Saneyoshi Wilmon F. Grant Victor Derkach Thomas R. Soderling

Members of the Wnt signaling family are important mediators of numerous developmental events, including activity-dependent dendrite development, but the pathways regulating expression and secretion of Wnt in response to neuronal activity are poorly defined. Here, we identify an NMDA receptor-mediated, Ca2+-dependent signaling pathway that couples neuronal activity to dendritic arborization thro...

2015
Jing Li Ling Ji Jieping Chen Wengeng Zhang Zhijia Ye

Cooperating with other signaling pathways, Wnt signaling controls cell proliferation, morphology, motility, and embryonic development destination and maintains the homeostasis of tissues including skin, blood, intestine, and brain by regulating somatic stem cells and their niches throughout adult life. Abnormal regulation of Wnt pathways leads to neoplastic proliferation in these tissues. Recen...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2011
Courtney T Griffin Carol D Curtis Reema B Davis Vijay Muthukumar Terry Magnuson

The ATP-dependent chromatin-remodeling enzyme brahma-related gene 1 (BRG1) regulates transcription of specific target genes during embryonic and postnatal development. Deletion of Brg1 from embryonic blood vessels results in yolk sac vascular remodeling defects. We now report that misregulation of the canonical Wnt signaling pathway underlies many Brg1 mutant vascular phenotypes. Brg1 deletion ...

2015
Michaela Bayerlová Florian Klemm Frank Kramer Tobias Pukrop Tim Beißbarth Annalen Bleckmann Wenqing Xu

INTRODUCTION WNT signaling is a complex process comprising multiple pathways: the canonical β-catenin-dependent pathway and several alternative non-canonical pathways that act in a β-catenin-independent manner. Representing these intricate signaling mechanisms through bioinformatic approaches is challenging. Nevertheless, a simplified but reliable bioinformatic WNT pathway model is needed, whic...

Journal: :Cell reports 2016
So-Young Hwang Xianming Deng Sanguine Byun Chan Lee Seung-Joo Lee Hyunsuk Suh Jianming Zhang Qiaofeng Kang Ting Zhang Kenneth D Westover Anna Mandinova Sam W Lee

The Wnt/β-catenin signaling pathway plays a major role in tissue homeostasis, and its dysregulation can lead to various human diseases. Aberrant activation of β-catenin is oncogenic and is a critical driver in the development and progression of human cancers. Despite the significant potential of targeting the oncogenic β-catenin pathway for cancer therapy, the development of specific inhibitors...

2010
Hanife Güler Mehmet Sinan BEKSAÇ

The Wnt signaling pathway is evolutionary conserved and controls many biological processes like cell proliferation and differentiation. It also provides planar polarity, regulation of the cell cycle, and cell adhesion during both the embryonic and adult period. However, it has been widely considered in the literature that some pathological alterations in various biomolecules involved in this pa...

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