نتایج جستجو برای: wnt

تعداد نتایج: 22773  

2018
Ofelia Tacchelly-Benites Zhenghan Wang Eungi Yang Hassina Benchabane Ai Tian Michael P Randall Yashi Ahmed

The aberrant activation of Wnt signal transduction initiates the development of 90% of colorectal cancers, the majority of which arise from inactivation of the tumor suppressor Adenomatous polyposis coli (APC). In the classical model for Wnt signaling, the primary role of APC is to act, together with the concentration-limiting scaffold protein Axin, in a "destruction complex" that directs the p...

2015
Mirza A Hammad Syed Sikander Azam

Wnt-4 (wingless mouse mammary tumor virus integration site-4) protein is involved in many crucial embryonic pathways regulating essential processes. Aberrant Wnt-4 activity causes various anomalies leading to gastric, colon, or breast cancer. Wnt-4 is a conserved protein in structure and sequence. All Wnt proteins contain an unusual fold comprising of a thumb (or N-terminal domain) and index fi...

Journal: :Cancer research 2006
Manabu Kurayoshi Naohide Oue Hideki Yamamoto Michiko Kishida Atsuko Inoue Toshimasa Asahara Wataru Yasui Akira Kikuchi

Wnt-5a is a representative ligand that activates a beta-catenin-independent pathway in the Wnt signaling. Although abnormal activation of beta-catenin-dependent pathway is often observed in human cancer, the relationship between beta-catenin-independent pathway and tumorigenesis is not clear. We sought to clarify how Wnt-5a is involved in aggressiveness of gastric cancer. Abnormal expression of...

ژورنال: Anatomical Sciences Journal 2011
Parvaneh Tafreshi, Azita, Safarpour, Atefeh, Zeynali, Bahman, Soleimani, Masoud,

Purpose: Bone defects caused by injuries, trauma, cancer, surgical operation or joint dislocation have great impacts on general health. Considering that Wnt signalling is one of the important regulators of the stem cell control, we sought to examine if Wnt activation affects the osteogenic differentiation of the USSCs.Materials and Methods: In this study, we have treated USSCs cultured in osteo...

2016
Babita Madan Zhiyuan Ke Zheng Deng Lei Frois Ashley Oliver Masanobu Oshima May Ann Lee Steve Rozen David M. Virshup

Activation of Wnt signaling due to Wnt overexpression or mutations of Wnt pathway components is associated with various cancers. Blocking Wnt secretion by inhibiting PORCN enzymatic activity has shown efficacy in a subset of cancers with elevated Wnt signaling. Predicting response to upstream Wnt inhibitors and monitoring response to therapeutics is challenging due to the paucity of well-define...

Journal: :International journal of computational biology and drug design 2012
Sudipto Saha Theodore Roman Alex Galante Mehmet Koyutürk Rob M. Ewing

Wnt signalling is a critically important signalling pathway regulating embryogenesis and differentiation, and is broadly conserved amongst multicellular animals. In addition, dysregulation of Wnt signalling contributes to the pathogenesis of many human cancers, in particular colorectal cancer. Core members of the Wnt signalling pathway are quite well defined, although it has become apparent tha...

Journal: :Cell reports 2012
Radek Dobrowolski Philipp Vick Diego Ploper Iwona Gumper Harriet Snitkin David D Sabatini Edward M De Robertis

Sustained canonical Wnt signaling requires the inhibition of glycogen synthase kinase 3 (GSK3) activity by sequestration of GSK3 inside multivesicular endosomes (MVEs). Here, we show that Wnt signaling is increased by the lysosomal inhibitor chloroquine, which causes accumulation of MVEs. A similar MVE expansion and increased Wnt responsiveness was found in cells deficient in presenilin, a prot...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2014
Si Hui Tan Kshemendra Senarath-Yapa Michael T Chung Michael T Longaker Joy Y Wu Roeland Nusse

Wnt signaling is a critical regulator of bone development, but the identity and role of the Wnt-producing cells are still unclear. We addressed these questions through in situ hybridization, lineage tracing, and genetic experiments. First, we surveyed the expression of all 19 Wnt genes and Wnt target gene Axin2 in the neonatal mouse bone by in situ hybridization, and demonstrated--to our knowle...

Journal: :Development 2007
Jennifer L Green Takao Inoue Paul W Sternberg

Inhibitors of Wnt signaling promote normal development and prevent cancer by restraining when and where the Wnt pathway is activated. ROR proteins, a class of Wnt-binding receptor tyrosine kinases, inhibit Wnt signaling by an unknown mechanism. To clarify how RORs inhibit the Wnt pathway, we examined the relationship between Wnts and the sole C. elegans ROR homolog, cam-1, during C. elegans vul...

2014
Katharina Seitz Verena Dürsch Jakub Harnoš Vitezslav Bryja Marc Gentzel Alexandra Schambony

β-Catenin independent, non-canonical Wnt signaling pathways play a major role in the regulation of morphogenetic movements in vertebrates. The term non-canonical Wnt signaling comprises multiple, intracellularly divergent, Wnt-activated and β-Catenin independent signaling cascades including the Wnt/Planar Cell Polarity and the Wnt/Ca(2+) cascades. Wnt/Planar Cell Polarity and Wnt/Ca(2+) pathway...

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