By WILLIAM C. MOLONEY, ANTONIO E. BOSCHETFI AND GERALDINE Down T HIS INVESTIGATION is concerned with studies on leukemia occurring in a series of noninbred Wistar and inbred Wistar Furth ( W/Fu ) rats treated with whole body x-ray and oral administration of 3 methylcholanthrene ( 3MCA ) . The animals were followed by serial leukocyte counts and examination of peripheral blood smears. At the tim...

Membrane microviscosity, phospholipid composition, and turnover were measured in cultured vascular smooth muscle cells isolated from mesenteric arteries of stroke-prone spontaneously hypertensive and age-matched, normotensive Wistar-Kyoto rats. Membrane microviscosity, measured with fluorescence polarization, revealed greater microviscosity (lower fluidity) of the membranes isolated from smooth...

BACKGROUND The aim of the present study was to examine if differences in the endocannabinoid (ECB) system might be linked to strain specific variations in reward-related behavior in Fischer344 (Fischer) and Wistar rats. METHODOLOGY/PRINCIPAL FINDINGS Two rat strains, the Fischer and the Wistar strain, were tested for different aspects of reward sensitivity for a palatable food reward (sweeten...

The Spontaneously-Running Tokushima Shikoku (SPORTS) strain is an original line derived from Wistar rats, which spontaneously runs >6 km/day on wheels, and has better glucose tolerance and less fat than Wistar rats. However, the molecular mechanism that contributes to the increased metabolic activity in SPORTS rats is unknown. The present study aimed to characterize the gene expression profiles...

Congenital toxoplasmosis was evaluated in Wistar and Holtzman rats using two strains of Toxoplasma gondii isolated in Brazil. Pregnant rats were inoculated by subcutaneous or intraperitoneal routes with 10(6) or 8 x 10(6) tachyzoites of N strain (virulent for mice) and by subcutaneous or oral routes with 10(2) or 1.2 x 10(3) cysts of P strain (avirulent for mice). The tissues of rat pups born f...

Pre-existing diabetes increases the risk of maternal and fetal complications during pregnancy, which may be due to underlying maternal vascular dysfunction and impaired blood supply to the uteroplacental unit. Endothelial dysfunction and reduced vascular smooth muscle responsiveness to nitric oxide (NO) are common vascular impairments in type 2 diabetes (T2D). We hypothesized that uterine arter...

Background. Many investigators have observed differences in the susceptibility to induce intestinal tumors by 1,2-dimethylhydrazine (DMH) between various strains of rodents. The results are difficult to compare because of the different regimes used for induction. The purpose of our study was to evaluate the influence of strain on DMH-induced intestinal tumors between Wistar and Fischer rats. Ma...

Introduction: Gingiva is one of the oral mucosa that most susceptible to injury, factors surgical procedures such as curettage which will be followed by a natural wound healing process. When occurs, cells act building blocks ground substance and formation collagen fibers in closing are fibroblast cells. Many people think earthworms (Lumbricus rubellus) only animal feed or fish feed, but have ma...

Introduction: Insulin dependant diabetes mellitus (IDDM) is an autoimmune disease that disrupts the body’s ability to produce insulin, and thus regulate the level of glucose in the blood. IDDM is associated with numerous systemic complications, including the impairment of fracture healing. Common problems include delayed unions, non-unions, and pseudoarthrosis. Previous studies conducted in our...

A defined model system which may have relevance to "spontaneous" tumors was described. Cells derived from normal germ-free Wistar rat embryos were propagated in vitro and showed morphologic conversion to epithelium-like cells on the 8th passage. The 19th passage in vitro of the converted cells induced progressively growing local fibrosarcomas in newborn rats; the tumors were not transplantable ...