The rank statistics Sn(t) = 1 n ∑n i=1 ciRi(t) (t ∈ R), with Ri(t) being the rank of ei−txi, i = 1, . . . , n and e1, . . . , en being the random sample from the basic distribution with the cdf F , are considered as a random process with t in the role of parameter. Under some assumptions on ci, xi and on the underlying distribution, it is proved that the process {Sn( t √n)− Sn(0)− ESn(t), |t|2 ...

Obstructive sleep apnea syndrome (OSA) and restless legs syndrome (RLS) with periodic limb movement during sleep (PLMS) are two sleep disorders characterized by repetitive respiratory or movement events associated with cortical arousals. We compared the cerebral hemodynamic changes linked to periodic apneas/hypopneas with arousals (AHA) in four OSA-patients with periodic limb movements (PLMA) w...

When evaluating differences between competing precipitation forecasts, formal hypothesis testing is rarely performed. This may be due to the difficulty in applying common tests given the spatial correlation of and nonnormality of errors. Possible ways around these difficulties are explored here. Two datasets of precipitation forecasts are evaluated, a set of two competing gridded precipitation ...

Idiopathic pulmonary fibrosis (IPF) is the most common interstitial pneumonia and the most aggressive interstitial lung disease. Usually, IPF is confirmed by the histopathological pattern of typical interstitial pneumonia and requires an integrated multidisciplinary approach from pulmonologists, radiologists and pathologists. However, these diagnoses are performed at an advanced stage of IPF. A...

MOTIVATION An important application of microarray experiments is to identify differentially expressed genes. Because microarray data are often not distributed according to a normal distribution nonparametric methods were suggested for their statistical analysis. Here, the Baumgartner-Weiss-Schindler test, a novel and powerful test based on ranks, is investigated and compared with the parametric...

The hypothesis that altered expression of specific coactivators/repressors of the estrogen receptor occurs during human breast tumorigenesis in vivo is examined in this study. Using in situ hybridization and reverse transcription-PCR assays, the expression of two coactivators (SRA and AIB1) and one repressor (REA) of the estrogen receptor was compared between matched breast tumors and adjacent ...

The hypothesis that altered expression of specific coactivators/repressors of the estrogen receptor occurs during human breast tumorigenesis in vivo is examined in this study. Using in situ hybridization and reverse transcription-PCR assays, the expression of two coactivators (SRA and AIB1) and one repressor (REA) of the estrogen receptor was compared between matched breast tumors and adjacent ...

CONTEXT Hospice care may improve the quality of end-of-life care for nursing home residents, but hospice is underutilized by this population, at least in part because physicians are not aware of their patients' preferences. OBJECTIVE To determine whether it is possible to increase hospice utilization and improve the quality of end-of-life care by identifying residents whose goals and preferen...

The massive surge in the production of microarray data poses a great challenge for proper analysis and interpretation. In recent years numerous computational tools have been developed to extract meaningful interpretation of microarray gene expression data. However, a convenient tool for two-groups comparison of microarray data is still lacking and users have to rely on commercial statistical pa...

In comparing the mean count of two independent samples, some practitioners would use the t-test or the Wilcoxon rank sum test while others may use methods based on a Poisson model. It is not uncommon to encounter count data that exhibit overdispersion where the Poisson model is no longer appropriate. This paper deals with methods for overdispersed data using the negative binomial distribution r...