UNLABELLED Sequencing reads generated by RNA-sequencing (RNA-seq) must first be mapped back to the genome through alignment before they can be further analyzed. Current fast and memory-saving short-read mappers could give us a quick view of the transcriptome. However, they are neither designed for reads that span across splice junctions nor for repetitive reads, which can be mapped to multiple ...

MOTIVATION PacBio sequencers produce two types of characteristic reads (continuous long reads: long and high error rate and circular consensus sequencing: short and low error rate), both of which could be useful for de novo assembly of genomes. Currently, there is no available simulator that targets the specific generation of PacBio libraries. RESULTS Our analysis of 13 PacBio datasets showed...

Concurrent programs executing on NUMA architectures consist of concurrent entities (e.g. threads, actors) and data placed on different nodes. Execution of these concurrent entities often reads or updates states from remote nodes. The performance of such systems depends on the extent to which the concurrent entities can be executing in parallel, and on the amount of the remote reads and writes. ...

The aim of this work is to present the constitutional law-making process in Commonwealth Poland, which was established as a merger Poland and Lithuania 1569. system state defined constitution Coronation Sejm King Stefan Batory 1576, adopted on basis resolution prepared during Election first elected king, Henry de Valois, 1573. provisions were called Articuli Henriciani after king. provided for ...

A century ago, on October 28th Benito Mussolini and twenty thousand members of his National Fascist Party marched Rome. Prime minister Luigi Facta assured the king that Italian armed forces could resist few march suggested declaring a state emergency. King Victor Emmanuel III elite for two years had been watching with apprehension rise communist left sought strong hand to curb disorders. was co...