Genotyping was done using ARMS-PCR for rs1333049 and rs10757274 in their study. When we first looked at the genotype frequencies, we observed a substantial excess of heterozygote subjects for both SNPs. Specifically, the relative excess of heterozygosity (REH) (2), a measure for the strength of deviation from Hardy-Weinberg equilibrium (HWE), was approximately 137% for rs1333049 in controls (RE...

Using singular perturbation methods, the existence and stability of traveling wave solutions for a density-dependent selection migration model in population genetics is proved. Single locus and two alleles are assumed, and it is also assumed that the fitnesses of the heterozygotes in the population are close to but below those of the homozygotes. Unlike previous models, this paper does not assu...

Hardy-Weinberg equilibrium and neutrality are assumptions shared by all measures of genetic distance and structure computed in the present report. In order to evaluate the impact of ignoring departures from these theoretical models, we calculated Reynolds’ distance, FST, Nei’s D and ancestry coefficients using two sets of markers: all 127 markers passing quality control ( ) and a reduced panel ...

In this paper, we review and explore some important aspects of a key project on applied statistical methods supported by the National Natural Science Foundation of China. Our discussion focuses on (1) statistical inference under order restriction, (2) structural learning of graphical models, and (3) statistical analysis on haplotypes and recombination fractions in genetics and some research res...

Galium catalinense subspecies acrispum (Rubiaceae) is a state-endangered perennial shrub endemic to San Clemente Island. Eight polymorphic microsatellite loci were isolated from G. catalinense ssp. acrispum. These loci show high levels of variability, averaging 6.5 alleles per locus and an expected heterozygosity of 0.550. One locus exhibited significant deviations from Hardy-Weinberg equilibri...

We calculate the effective action of a superconductor, without assuming that either the electron-electron potential or the Fermi surface obey rotational invariance. This approach leads to the same gap equation and equilibrium free energy as more conventional methods. The results are used to obtain the Gell-Mann Low renormalization group equations for the electron-electron potential. Research su...

The acquired prion disease kuru was restricted to the Fore and neighbouring linguistic groups of the Papua New Guinea highlands and largely affected children and adult women. Oral history documents the onset of the epidemic in the early twentieth century, followed by a peak in the mid-twentieth century and subsequently a well-documented decline in frequency. In the context of these strong assoc...

Uredinia of poplar leaf rust, Melampsora medusae Thüm f.sp. deltoides, appeared in late July 1998, June 1999, and August 2000 in a cottonwood (Populus deltoides Bartr.) stand in Ames, Iowa. Seedlings of the alternate host (eastern larch, Larix laricina (Du Roi) K. Koch) set out at the site in spring 2000 formed aecia 3 months before uredinia appeared. Using three PCR-based microsatellite marker...