Abstract Cardiovascular disease is the leading cause of mortality worldwide, affecting a wide range patients at different stages across cardiovascular continuum. Hypertension one earliest risk factors in this continuum and can be controlled most with currently available antihypertensive agents. However, goals are often not met because treatments optimized terms tailoring therapy to individual b...

Malware analysis relies heavily on the use of virtual machines for functionality and safety. There are subtle differences in operation between virtual machines and physical machines. Contemporary malware checks for these differences to detect that it is being run in a virtual machine, and modifies its behavior to thwart being analyzed by the defenders. Existing approaches to uncover these diffe...

BACKGROUND Guidelines for the management of hypertension recommend the use of drugs with different mechanisms of action in antihypertensive regimens that include single-pill fixed-dose combinations of medications. There is some controversy regarding which single-pill fixed-dose combinations of angiotensin II type 1 receptor blockers (ARBs) and calcium channel blockers (CCBs) are effective at re...

OBJECTIVE Studies have shown poor knowledge of oral contraceptives among women attending government health clinics and women in rural areas. Little is known about the level of contraceptive knowledge in educated, affluent, career-orientated women, although it could be expected that access to information would be greater. The study objective was to describe the profile, knowledge and understandi...

Contraceptive failure and the progestogen-only pill The case report by Chandler and Nash1 in this issue of the Journal is interesting and highlights the need for trials of hormonal contraceptive use to include obese women. The authors acknowledge that despite an apparent association between contraceptive failure and higher body weight in studies of a Norplant® prototype and a levonorgestrelrele...

This study aimed to investigate the association between sleeping pill use and hypertension or blood pressure (BP) via a cross-sectional analysis.A total of 11,225 subjects (5875 men and 5350 women) underwent health examinations. We compared the proportion of sleeping pill users among hypertension (n = 5099) and normotensive (n = 6126) participants. We analyzed participants with no intake of ant...

CONTEXT Studies suggest that women in some countries have adopted emergency contraceptive pills as a routine method of family planning. This practice indicates there may be latent demand for a pericoital contraceptive pill taken only when a woman has sexual intercourse, and labeled and marketed for use as a regular contraceptive method. METHODS To understand the appeal and potential market fo...

INTRODUCTION Emergency contraceptive pills (ECPs) were developed and marketed with the emergency aspect firmly in mind, but research and anecdotal evidence indicate that some women use them as a form of regular contraception, spurring efforts in the reproductive health community to explore the development of a coitally-dependent oral contraceptive pill. METHODS We asked women of reproductive ...