Antigen receptor ligation-induced apoptosis is thought to play a role in self-tolerance by deleting autoreactive lymphocytes. Antigen receptor ligation-induced apoptosis of mature T cells and T cell lines requires autocrine or paracrine activation of Fas (CD95/APO-1). Whether B cell antigen receptor (BCR)-mediated apoptosis requires Fas or related molecules is unclear. Here we demonstrate that ...

This study examined the development of subclones of different proliferative capacity and malignancy in the WEHI-7 tumor. The mouse T-cell lymphoma WEHI-7 can be cloned in agar with a cloning efficiency of 40 to 50%. On the basis of growth mor phology, two types of colonies were distinguished. Most colonies were compact, but a few, no more than 5%, were diffuse. Sublines of the two colony types ...

introduction: different microbial compounds can induece maturation of dendritic cells (dcs) into dc1 or dc2 .in the present study, we used tumor antigen pulsed dendritic cell that matured with listeria monocytogenes antigen and cholera toxin (ct) in the treatment of a murin model of cancer. material and methods: tumor cells (wehi-164 balb/c derived fibrosarsoma) were injected subcutaneously to ...

Profile Suzanne Cory: from a table to the top Matthijs J. Smith Suzanne Cory has recently been appointed to the directorship of Australia's premier biomedical research facility, the Walter and Eliza Hall Institute in Melbourne where, together with her husband Jerry Adams, she has headed the Molecular Biology Unit for the past 24 years. Their introduction of molecular biology into an environment...

(4) Consider the point y = (1/2, 0, 0) ∈ Ω. Is y an interior point of Ω? Characterize all the feasible directions e = (e1, e2, e3) ∈ R at y (a picture could help). Is y a (strict) local maximizer of f? (5) Consider the point z = (1/2, 1/2, 1/2) ∈ Ω. Is z an interior point of Ω? Characterize all the feasible directions e = (e1, e2, e3) ∈ R at z. Is z a (strict) local maximizer of f? What is the ...

Multidrug-resistant Acinetobacter baumannii is one of the most important pathogens in intensive care units related to morbidity and mortality. Colistin is being used increasingly as “salvage” therapy for these patients. However, resistance to colistin in A. baumannii has recently been reported. We herein present a case in which ventilator-associated pneumonia due to A. baumannii developed in on...