BACKGROUND Overweight and obesity are common among patients with Cushing's syndrome (CS) and may persist in some patients even after ostensibly curative surgery, contributing to cardiometabolic dysfunction and increased cardiovascular risk. Mifepristone, a selective glucocorticoid receptor antagonist, was effective in controlling hyperglycemia in a 24-week trial of adults (N = 50) with endogeno...

INTRODUCTION A 12-week prospective study was previously performed to assess the effect of add-on therapy with sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, in patients with type 2 diabetes mellitus (T2DM) receiving insulin treatment. Patients were followed until week 48 to investigate the medium-term efficacy and safety of the add-on therapy with sitagliptin. METHODS In the 70 pati...

Numerous studies have found that increased body size (weight or body mass index) is a risk factor for breast cancer development, recurrence, and death. The detrimental relationship between body size and breast cancer recurrence may be more pronounced among women with estrogen receptor (ER)/progesterone receptor (PR)-negative breast cancer. Considering the limited availability of treatments, and...

this experiment was conducted to investigate the effects of using protexin, propionic acid growth promoters, and a blend of them on broilers performance. in a completely randomized design, three hundreds and twenty unsexed 1-d-old chicks were divided into four groups. dietary treatments were consisted of 1) control diet without any supplement, 2) the control diet + 0.01 % protexin, 3) the contr...

This was designed to see the possible effects of olive oil on liver and body weight of albino rats. For this purpose, 50 albino rats of eight weeks age were selected and divided into five groups of ten animals each with equal number of males and females. Group I, normal control, was fed on synthetic diet, group II was on low olive oil diet only and group III was on low olive + hypercholesterole...

OBJECTIVE Zonisamide and bupropion have been investigated for weight reduction in obese adults. We conducted a preliminary study comparing the effect on body weight of the combination of these 2 drugs versus zonisamide monotherapy. METHOD This was a 12-week, randomized, open-label, parallel-group comparison of 2 active interventions conducted from October 2003 to June 2004. Eighteen obese wom...

Open Access Week, starting 24 October 2016, is a worldwide event established to promote the potential benefits of open access and to foster wider participation in helping to make open access the norm in research and information sharing. In its eighth year, Open Access Week presents an opportunity for funding bodies, universities and others to use the context to advance policy changes in favour ...