Major recent improvements of the efficacy of systemic therapies have challenged the fact that patients with metastases should only be managed in a palliative intent. This is particularly relevant for patients with brain metastases. In these patients, the suboptimal results of historical whole-brain radiation therapy (WBRT) have encouraged new strategies for optimizing control of intracranial me...

Abstract AIMS Small cell lung cancer (SCLC) brain metastases (BM) are common at both presentation and relapse. Historically, BM managed with whole radiotherapy (WBRT) +/- chemotherapy. However, WBRT is associated significant cognitive impairment, so interest in the focal management of (encompassing stereotactic radiosurgery (SRS) surgery) increasing. We systematically reviewed current literatur...

: Development of brain metastases are common in patients with advanced malignancies leading to significant morbidity and mortality. Although overall survival is an important endpoint these patients, neurocognition health related quality life (HRQoL) more accurately highlights the impact disease its treatment on patients. Whole radiotherapy (WBRT) has historically played a key role management es...

BACKGROUND To evaluate the local control of brain metastases (BM) in patients treated with stereotactic radiosurgery (SRS), correlate the outcome with treatment parameters and lesion characteristics, and define its implications for clinical decisions. METHODS Between 2007 and 2012, 305 BM in 141 consecutive patients were treated with SRS. After exclusions, 216 BM in 100 patients were analyzed...

Lung cancer is the second commonest cancer in the UK with an incidence in 2006 of 37 100, and is the commonest cause of death from cancer, causing more than 33 000 deaths (22% of cancer deaths) each year. More than three-quarters of lung cancers fall into the histological category of non-small cell lung cancer (NSCLC). Currently, 10% of patients with NSCLC present with symptomatic brain metasta...

PURPOSE To assess the radiation dose delivered to the heart and ipsilateral lung during accelerated partial breast brachytherapy using a MammoSite applicator and compare to those produced by whole breast external beam radiotherapy (WBRT). MATERIALS AND METHODS Dosimetric analysis was conducted on patients receiving MammoSite breast brachytherapy following conservative surgery for invasive duc...

PURPOSE Given the neurocognitive toxicity associated with whole-brain irradiation (WBRT), approaches to defer or avoid WBRT after surgical resection of brain metastases are desirable. Our initial experience with stereotactic radiosurgery (SRS) targeting the resection cavity showed promising results. We examined the outcomes of postoperative resection cavity SRS to determine the effect of adding...

PURPOSE To investigate treatment options for local control of metastasis in the brain, we compared focal brain treatment (FBT) with or without whole brain radiotherapy (WBRT) vs. WBRT alone, for breast cancer patients with tumor relapse in the brain. We also evaluated treatment outcomes according to the subtypes. METHODS We conducted a retrospective review of breast cancer patients with brain...

PURPOSE To improve survival and reduce toxicity in primary CNS lymphoma (PCNSL) treatment, we conducted a multicenter phase II study with early high-dose chemotherapy (HDT) and autologous stem-cell transplantation (ASCT) followed by hyperfractionated whole-brain radiotherapy (WBRT) for newly diagnosed PCNSL patients younger than 65 years of age. PATIENTS AND METHODS Chemotherapy included thre...

BACKGROUND We investigated the efficacy and safety of tandem high-dose methotrexate (HD-MTX) induction followed by high-dose busulfan/thiotepa (HD-BuTT) with autologous peripheral blood stem-cell transplantation (aPBSCT) and response-adapted whole-brain radiation therapy (WBRT) in patients with newly diagnosed primary central nervous system lymphoma. PATIENTS AND METHODS Twenty-three patients...