To enable large-scale reactive dynamic simulations of copper oxide/water and copper ion/water interactions we have extended the ReaxFF reactive force field framework to Cu/O/H interactions. To this end, we employed a multistage force field development strategy, where the initial training set (containing metal/metal oxide/metal hydroxide condensed phase data and [Cu(H(2)O)(n)](2+) cluster struct...

Each generation of digital innovation has caused a dramatic change in the way people work. Sharing economy is the latest trend of digital innovation, and it has fundamentally changed the traditional business models. In this paper, we empirically examine the impacts of the sharing economy platforms (specifically, Uber) on the labor market in terms of labor force participation, unemployment rate,...

Viral entry into the host cell is the first step of virus infection; however, its dynamic process via endocytosis remains largely elusive. Here, the force tracing technique and single particle simulation are combined to investigate the invagination of single human enterovirus 71 (HEV71, a positive single-stranded RNA virus that is associated with hand, foot, and mouth disease) via cell membrane...

For the past two years, France has enjoyed fertility rates approaching replacement level, with a total fertility rate of 1.98 in 2006 and 2.00 in 2008. After a ten-year period of slow growth, the fertility rate has thus reached its highest level in about thirty years (Prioux, 2007), placing France in top position among European and other OECD countries. However, this high level of fertility is ...

Temperature control during the cutting process with different parameters such as cutting velocity and applying water cooling is essential to decrease the cutting force, increase the life of the cutting tool and decrease the machined surface temperature of work-piece. In this research, the temperature of machined surface and the chip-tool interface in orthogonal cutting process of Ti-6Al-4V were...

Water solubility is an important characteristic of a chemical in many aspects. However experimental definition of the endpoint for all substances is impossible. In this study quantitative structure-property relationships (QSPRs) for negative logarithm of water solubility-logS (mol L(-1)) are built up for five random splits into the sub-training set (≈55%), the calibration set (≈25%), and the te...

Muscles that are stretched during contraction (eccentric contractions) show deficits in force production and a variety of structural changes, including loss of antibody staining of cytoskeletal proteins. Extracellular Ca(2+) entry and activation of calpains have been proposed as mechanisms involved in these changes. The present study used isolated mouse extensor digitorum longus (EDL) muscles s...

In about half of patients infected with HIV-1 subtype B, viral populations shift from utilizing the transmembrane protein CCR5 to CXCR4, as well as or instead of CCR5, during late stage progression of the disease. How the relative adhesion efficiency and fusion competency of the viral Env proteins relate to infection during this transition is not well understood. Using a virus-cell fusion assay...