Groundwater age, and its influence on contemporary water chemistry, needs to be accurately described to quantify the temporally varying impacts of land use on water quality. The time lags between solute inputs at the land surface and impacts on stream chemistry can be an important factor for managing land use in regional watersheds. Our approach uses a modified groundwater flow code to simulate...

[1] We study and explain the origin of early breakthrough and long tailing plume behavior by simulating solute transport through 3-D X-ray images of six different carbonate rock samples, representing geological media with a high degree of pore-scale complexity. A Stokes solver is employed to compute the flow field, and the particles are then transported along streamlines to represent advection,...

This paper reviews the use of texture analysis in studying the performance of hydrophilic matrices of highly soluble drugs and different types of excipients (i.e. water-soluble, water-insoluble and swellable, and water insoluble and non-swellable). Tablets were prepared by direct compression, and their swelling and erosion in presence of these different excipients were assessed with the help of...

A mathematical model is presented to simulate water and solute transport in a highly viscous fluid with a water-permeable, elastic immersed membrane. In this model, fluid motion is described by Stokes flow, whereas water fluxes across the membrane are driven by transmural pressure and solute concentration differences. The elastic forces, arising from the membrane being distorted from its relaxe...

Kidney transplantation, especially when associated with acute rejection, leads to changes in the expression of many genes, including those encoding solute transporters and water channels. In a rat model of acute rejection after allogeneic renal transplantation, impaired renal function, increased urine volume, and increased fractional excretion of sodium were observed. Gene array analysis reveal...

Mathematical models of renal tubular function, with detail at the cellular level, have been developed for most nephron segments, and these have generally been successful at capturing the overall bookkeeping of solute and water transport. Nevertheless, considerable uncertainty remains about important transport events along the nephron. The examples presented include the role of proximal tubule t...