The bioavailability and intrinsic toxicity of many potential drugs affect their pharmacological profile and, in turn, their therapeutic efficacy and therefore, preventing them from late-stage pharmaceutical development. Hence, pharmaceutical industries are recently being forced to renew creatively their drug discovery programs and design more and better drug candidates for clinical development....

During the bull-nose end milling operations of thin-walled structures, chatter usually occurs and adversely affects cutter performance, finished surface quality, production efficiency. To accurately predict stability, a suitable dynamic model with effective system parameters is required. In this article, three-degree-of-freedom (3-DOF) developed to analyze stability cylinders, in which dynamics...

Oxygen is crucial to maintain and save human life. Other than medical purposes it is widely used for manufacture of mineral water, fabrication works and other industrial activities. If adequate precautionary measures are not adopted while handling, storage or transport of oxygen cylinder or container, accidental blast may claim human life and other damage as well. The case involving three victi...

The most frequent and expensive cause category of compensable loss is manual material handling (MMH). Casting workers who handle oxygen (O2) cylinders manually are at risk for work-related musculoskeletal disorders (WMSDs). The aim of this study was to assess manual handling of O2 cylinders by casting workers and to implement ergonomic intervention to reduce the risk of musculoskeletal disorder...

This research investigates the effect of post-cure time on residual stresses in laminated composites. Laminated composites were made of T300 carbon fibers and epoxy resin. The post-cure process was carried out at the constant temperature of 120 °C for 6 and 12 hours for two specimens. The slitting method was employed to determine through-thickness residual stress distribution of the composite l...

A new closed form formulation of three-dimensional (3-D) refined higher-order shell theory (RHOST) to analyze the free vibration of composite circular cylindrical shells has been presented in this article. The shell is considered to be laminated with orthotropic layers and simply supported boundary conditions. The proposed theory is used to investigate the effects of the in-plane and rotary ine...

in design and optimization process of laminated composite structures, the number of layers, layer angles, stacking sequence, material types and etc should be specified. each of aforesaid parameters can be applied as a design variable. in this paper the target is to minimize the weight of laminated composite pin loaded structures. the laminated composite structures are designed based on the load...

Protective clothing performs a vital role in maintaining the safety of human in workplace. The developments in this field are proceeding to fulfill the needs with multifunctional materials at competitive costs. Recently, the protective clothing field introduces the usage of composite materials taking advantage of their outstanding properties. In this paper, the multifunctional performance of hy...