This thesis is an investigation of the behaviour of radial progenitors in the hindbrain of the teleost fish Danio rerio, the zebrafish, during embryonic neurogenesis. These progenitors have many of the characteristics of radial glial cells described in other systems. Recent studies from several laboratories worldwide have shown that radial glia play an important role in the patterning and neuro...

The developmental stage at which nerve cells initially express specific neurotransmitters and their corresponding receptors remains elusive. In the present study, the distribution patterns of transcripts for the GABA-synthesizing enzyme, glutamate decarboxylase (GAD,,), and specific GABA, receptor subunits were examined in the proliferative zone of the rat central nervous system using in situ h...

Evidence from several brain regions suggests gamma-aminobutyric acid (GABA) can exert a trophic influence during development, expanding the role of this amino acid beyond its function as an inhibitory neurotransmitter. Proliferating precursor cells in the neocortical ventricular zone (VZ) express functional GABA(A) receptors as do immature postmigratory neurons in the developing cortical plate ...

Although 20(S)-camptothecin (CA) exhibited potent cytotoxicity against a broad spectrum of tumor models, clinical trials with the sodium salt of its opened lactone ring form were discontinued due to highly variable and severe toxicity. Recently, the 9-amino (AC) and 10,11-methylenedioxy (MC) derivatives of CA were selected for preclinical evaluation by the National Cancer Institute. In the pres...

Recent theoretical work [1] suggested the longitudinal velocities of the fragmentation residues produced in relativistic heavy-ion collisions as an observable sensitive to the momentum dependent (MD) properties of the nuclear mean field (MF). Under certain conditions, the spectator remnant can acquire on average even a positive momentum during the collision This phenomenon has been named specta...

In this paper a new class of meromorphic univalent functions in terms of an integral operator F c (z) = 1 0 cv c f (vz)dv, (c ≥ 1), is defined. We fined some properties of this new class by using of two fixed points.

During neurogenesis in the embryonic cerebral cortex, the classical neurotransmitters GABA and L-glutamate stimulate ionic conductance changes in ventricular zone (VZ) neuroblasts. Lysophosphatidic acid (LPA) is a bioactive phospholipid producing myriad effects on cells including alterations in membrane conductances (for review, see Moolenaar et al., 1995). Developmental expression patterns of ...

OBJECTIVE An extended-release amphetamine (AMP) oral suspension has been developed to facilitate medication ingestion and dose titration. This study sought to determine the pharmacokinetic (PK) profile of this new formulation in children with attention-deficit/hyperactivity disorder (ADHD). METHODS This was an open-label, single-period, PK study in 29 pediatric participants with ADHD. Partici...

II. Relaxation Time and the Deborah Number NB In what follows we use viscometric information from Note I ( Fluid Rheology). To determine the Deborah number for the axisymmetric contraction-expansion we need to select both a characteristic timescale for the flow and a representative measure of the spectrum of relaxation times of the fluid. A characteristic strain rate based on the local flow con...

BACKGROUND A novel formulation for treating attention-deficit/hyperactivity disorder (ADHD) has recently been developed-amphetamine extended-release orally disintegrating tablets (AMP XR-ODTs). In this study, we assessed the rate of absorption and exposure of AMP XR-ODT under fasted conditions in children with ADHD. METHODS Children (6-12 years) with ADHD were enrolled in a single-dose, open-...