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BACKGROUND Disruption of ROBO2 in humans causes vesicoureteral reflux (VUR)/congenital anomalies of the kidney and urinary tract (CAKUT). PiggyBac (PB) is a DNA transposon, and its insertion often reduces-but does not eliminate-gene expression. The Robo2 insertion mutant exhibited non-dilating VUR, ureteropelvic junction obstruction (UPJO) not found in reported models. We studied the incidence ...

vesicoureteral reflux (vur) is a relatively common and important entity in children. vur can expose patient to risk of pyelonephritis, permanent renal damage or scar. vur itself has no deleterious effect on kidney parenchyma until the development of infection or increased intravesical pressure.   the diagnosis of vur could lead to appropriate therapy and prevention of long term complications. t...

OBJECTIVE To examine whether factors in a child's perinatal history influence renal function in adolescence, using a cross-sectional study, as during the past two decades researchers have tried to ascertain whether factors such as low birth weight might be related to a decline in kidney function in adolescence, although published data for children born with vesico-ureteric reflux (VUR) remain i...

BACKGROUND Radionuclide techniques, as direct radionuclide cystography and (99m)Tc-DMSA scintigraphy, have been used in evaluation of vesicoureteral reflux (VUR) and reflux nephropathy (RN) in children. Dynamic (99m)Tc-DTPA scintigraphy is reserved for evaluation of differential renal function and obstruction in children, where hydronephrosis is detected by ultrasonography (US) pre- or postnata...

Correspondence to: Rejane de Paula Bernardes. Nefrokids Clinic Curitiba. Rua Brasilio Itibere, no 3933. Curitiba, PR, Brasil. CEP: 80240-060. E-mail: [email protected] Over 4 decades ago, Hodson & Edwards1 described the association between chronic pyelonephritis and vesicoureteral reflux (VUR). Soon after, the term “reflux nephropathy” started to be used. Since then, urinary tract infecti...

vesico-ureteral reflux (vur) is presented in approximately %1 of children and is associated with an increased risk of pyelonephritis and renal scarring. despite its prevalence and morbidity, many aspects of vur diagnosis and treatment are controversial. we objectively assessed the published data; the data base for many current diagnoses and treatment patterns of vur is limited. recent studies h...

OBJECTIVES Vesicoureteric reflux (VUR) is a common cause of urinary tract infections in children, being less commonly diagnosed in adults. Several anti-reflux plasties have been used successfully for the treatment of such condition, such as Politano-Leadbetter, Cohen and Gregoir-Lich techniques, the latter being our preferred approach in open procedures. Here we describe our experience with lap...

INTRODUCTION VUR in spinal cord injured patients is cause of important morbidity and mortality. The aim of this paper is to make a statistical, retrospective and descriptive study to analyze VUR treatment results, in neurogenic bladder SCI patients. MATERIAL AND METHOD We study 40 patients (80 renal units) with VUR in neurogenic bladders and SCI, between March, 1990 and November, 2004. Median...