BACKGROUND Lichen planus (LP) is a mucocutaneous inflammatory dermatosis that frequently involves the oral and genital mucosae. Patients with LP affecting these sites are often seen by oral medicine specialists or gynaecologists who work in isolation and depend heavily on histopathologists to help them in confirming the diagnosis. There are few studies in the literature combining the experience...

Objective-To study efficacy of treatment of ifiarial lymphoedema and elephantiasis with 5,6-benzo-a-pyrone. Design-Randomised, double blind, placebo controlled study with matching for grade and duration of disease, age, and sex. Treatment was given for 367 days, and subjects were followed up for another year. Setting-A town in Shandong Province, China. Subjects-104 men and women with chronic un...

every Fijian is the subject of filariasis. These reasons, together with the preceding (1) are: (a) adult filarioe are to be found in the lymphatics and other tissues without the presence in the blood of corresponding microfilariae ; (b) a large proportion of Fijians are effected with what in common with others I regard as filarial disease, and in whom no microfilarire can be found in the blood....

Oscheius tipulae is a common soil nematode of the same family as C. elegans (Rhabditidae), which presents the same hermaphroditic mode of reproduction and is easily cultured in the same conditions. Oscheius tipulae has been used as a developmental genetic model system to study vulva formation. Compared to C. elegans, it has a simpler vulval cell lineage, a reduced competence group and a differe...

AIMS Aggressive angiomyxoma of pelvic parts is a distinctive soft tissue tumour that chiefly involves the vulvar and perineal region of female patients. Several previous reports have demonstrated oestrogen receptor (ER) and/or progesterone receptor (PR) positivity in this neoplasm. The aim of this study was to confirm whether ER and/or PR positivity is present in aggressive angiomyxoma. We also...

The recent outbreaks of sexually transmissible infections (STI) provoke professional concern and public anxiety. There is sporadically published literature reporting cases of vulval, penile and anal cancers presenting at genitourinary medicine clinics. The recent referral of a series of cases, by medical practitioners, as anogenital warts, which were later diagnosed as vulval, penile and anal c...

A current model for Caenorhabditis elegans vulval cell fate specification is that SynMuv genes act redundantly in the hyp7 hypodermal syncytium to repress the LIN-3/EGF inducer and prevent ectopic vulval induction of vulva precursor cells (VPCs). Here we show that the SynMuv gene hpl-2/HP1 has an additional function in VPCs, where it may act through target genes including LIN-39/Hox.

INTRODUCTION The complications of HIV/AIDS can produce grossly abnormal pathology. In low-resourced settings, women can present late with huge lesions. Massive vulval pathology copresenting in pregnancy produces difficulties in managing the patients and may lead to poor maternal or fetal outcomes. CASE REPORT A 27-year-old P1 G2 (second pregnancy one live birth) patient presented at 30 weeks ...