The objective of this study was to compare the in vitro behavior of four long-acting subcutaneous risperidone formulations with in vivo performance, with the intent of establishing an IVIVC. Two copolymers of PLGA (50:50 and 75:25) were used to prepare four microsphere formulations of risperidone, an atypical antipsychotic. In vitro behavior was assessed at the physiological temperature (37 °C)...

The objective of the study was to compare pharmacokinetic and pharmacodynamic parameters of gliclazide after administration of immediate (IR) and modified release (MR) tablets. The experiment included rats with both normoglyceamia and streptozocin (STZ)-induced hyperglyceamia. Several MR formulations were designed and in vitro drug release profile was assessed by a dissolution test. For the fur...

Small extracellular vesicles (sEV) purified from blood have great potential clinically as biomarkers for systemic disease; however interpretation is complicated by release of sEV ex vivo after taking. To quantify the problem and devise ways to minimise it, we characterised in paired serum, plasma platelet poor (PPP) samples healthy donors. Immunoblotting showed twofold greater abundance CD9 fra...

Peppermint oil (PO) is the most prominent using in pharmaceutical formulations with its significant therapeutic value. In this sense, attracting considerable attention from scientific community due to traditional claim, biological and pharmacological potential recent research. An organic solvent-free environment-friendly electrohydrodynamic assisted (EHDA) technique was employed prepared PO-loa...

The objective of the study was to compare pharmacokinetic and pharmacodynamic parameters of gliclazide after administration of immediate (IR) and modified release (MR) tablets. The experiment included rats with both normoglyceamia and streptozocin (STZ)-induced hyperglyceamia. Several MR formulations were designed and in vitro drug release profile was assessed by a dissolution test. For the fur...

buccal mucoadhesive films have attracted great attention among mucoadhesive systems due to their ability to adhere and remain on the oral mucosa and to release their drug content gradually. the aim of the current study was to formulate the ziziphus jujuba aqueous extract as buccal bioadhesive film, which continiously releases the drug at sufficient concentration for reducing the frequency of th...

objective: in order to overcome the limitation of systemic administration of methylene blue, this study investigated the encapsulation of methylene blue in polymeric liposomes and drug release following sonication. methods: we encapsulated methylene blue into nanoliposomes. the dynamic light scattering (dls) method was used to measure the size distribution of the liposomes. after loading methyl...

Tumor Immunotherapeutic Gels In article number 2204273, Dunfang Zhang, Hang Zhao, and co-workers demonstrate that an inosine-based supramolecular hydrogel, IPBisoG, can achieve the gradual sequential release of inosine aPDL1. Inosine, which enhancs proliferation function CD8+ T cells, together with aPDL1, blocker immunosuppressive pathway in tumor microenvironment, could highly enhance vivo eff...

This study aimed to predict the in vivo performance from the in vitro release of a low-molecular weight model compound, [(18)F]-2-fluoro-2-deoxy-d-glucose ([(18)F]FDG), from liposomes and by means of positron emission tomography (PET). Liposomes composed of hydrogenated phosphatidylcholine (HPC) were prepared by a freeze-thaw method. Particle size distribution was measured by dynamic light scat...

A variety of physiological and pathological factors induce cellular swelling in the brain. Changes in cell volume activate several types of ion channels, which mediate the release of inorganic and organic osmolytes and allow for compensatory cell volume decrease. Volume-regulated anion channels (VRAC) are thought to be responsible for the release of some of organic osmolytes, including the exci...