The aim of the present study was to investigate the potential of Transfersomal gel formulations for transdermal delivery of Celecoxib and to evaluate the effect of concentration of Soya PC and Sodium deoxycholate. Transfersomal vesicles containing Soya PC mixed with Sodium deoxycholate and Celecoxib were prepared by conventional rotatory evaporation (Film hydration method) and characterized for...

objective(s):drug delivery through the skin can transfer therapeutic levels of drugs for pharmacological effects. analgesics such as nsaids have gastrointestinal side effects and topical dosage forms of these drugs are mainly preferred, especially for local pains. meloxicam is one of nsaids with no topical form in the market. in this research, we attempted to quantify the skin permeation of a m...

Abstract Of the many roles that gastrointestinal tract (GIT) must facilitate, coordinated regulation of molecule movement across is key. This allows for nutrient absorption while limiting permeation non-desired molecules and referred to as barrier function. Barrier function GIT includes intrinsic, extrinsic, immunological factors, but generally permeability assessments are conducted evaluate wh...

Abstract: Background: The aim of this study was to enhance the solubility Natamycin, an antifungal agent used in fungal keratitis, through solid dispersion incorporated ophthalmic films with purpose avoid frequent dosing, period retention, and sustaining release for better patient compliance. Materials Methods: Firstly, dispersions were prepared by solvent evaporation method then, best formulat...

One of the cellular consequences of nitrosative stress is alkylation damage to DNA. To assess whether nitrosative stress is registered on the genome of Mycobacterium tuberculosis, mutants lacking an alkylation damage repair and reversal operon were constructed. Although hypersensitive to the genotoxic effects of N-methyl-N'-nitro-N-nitrosoguanidine in vitro, the mutants displayed no phenotype i...

The purpose of the study was to develop Tizanidine HCl (TZN) and Meloxicam (MLX) loaded bilayer mucoadhesive films intended for buccal administration, aiming to enhance the bioavailability. Bilayer films were prepared by solvent evaporation technique selecting arabinoxylan (ARX) as a sustained release (SR) layer forming polymer and hydroxypropyl methylcellulose (HPMC) E-15 as an immediate relea...

Background: in this paper, a new physical penetration technology for transdermal administration with traditional Chinese medicine (TCM) characteristics Fu’s cupping therapy (FCT) was established and studied by in-vitro and in-vivo experiments; the penetration effect and mechanism of FCT physical penetration technology (FCT-PPT) was preliminarily discussed. Method: Indomethacin (IM) as a model d...