Genipin-crosslinked chitosan hydrogels have gained attention as promising drug delivery vehicles. To bring them one step closer to clinical applications, this study evaluates the hydrogels' in vitro biocompatibility and biodegradation. Cytotoxicity test on 3T3 fibroblasts shows that cells retain normal adhesive properties high viability gels with 3.1 4.4 mm genipin but not 1.7 genipin. The high...

Abstract Cardiac valve replacement is an effective method to treat valvular heart disease. Artificial valves used routinely in clinic still have defects. In our study, we explored a novel modify the performance of Decellularized Heart Valve (DHV) scaffold. The decellularized porcine aortic was prepared using sequential hydrophile and lipophile solubilization method. sericin extracted from silk ...

In this paper, we present the physical properties and toxicological assessment of layers with nanoparticles based on metal chalcogenides titanium human fibroblast cells. Nanoparticles (MoS 2 , WS ZnS) were applied onto substrate by spray deposition method. flakes synthesized laser ablation fragmentation in liquid femtosecond pulses. We investigated size morphology nanoparticles: -based have a p...

Usually, before being used in biomedical applications, a biomaterials’ bioactivity is tested by vitro methods that simulate similar conditions to those found the human body. In this work, we report on synthesis of zinc-doped hydroxyapatite–chitosan (ZnHApC) composite coatings vacuum deposition method. The surface microstructure and chemical molecular modification after soaking DMEM (Dulbecco’s ...