PURPOSE Vascular endothelial growth factor (VEGF) concentrations in various regions of the vitreous were examined in patients with diabetic macular edema (DME) to explore the possibility of a concentration gradient in the vitreous. METHODS Vitreous samples were collected during vitrectomy from 71 eyes of 71 patients with DME and without posterior vitreous detachment who had not undergone panr...

Quality Protein Maize (QPM) is a hard kernel variant of the high-lysine mutant, opaque2. Using γ-irradiation, we created opaque QPM variants to identify opaque-2 modifier genes and to investigate deletion mutagenesis combined with Illumina sequencing as a maize functional genomics tool. A K0326Y-QPM deletion mutant (line 107) was null for the 27and 50-kD γ-zeins and abolished vitreous endosperm...

Different from most mammalian species, the optic nerve of the rabbit eye is initially formed inside the retina where myelination of the axons of the ganglion cells starts and vascularization occurs. Astrocytes are confined to these regions. The aforementioned nerve fibers known as medullated nerve fibers form two bundles that may be identified with the naked eye. The blood vessels run on the in...

To calculate and evaluate wave scattering and penetration of electromagnetic waves in different biological tissues it is necessary to use a realistic model of the human body, with all tissues resolved and separately assigned with appropriate electric/magnetic properties. We report the development of a realistic 3D whole-body human model that has been adapted for simulation in CST software, cont...

influence on its volume. For, from the physico-chemical point of view the vitreous body belongs to the hydrophil emulsoids and it is known that the degree of swelling of such emulsoids is dependent, among otlher factors, chiefly on the acid-base equilibrium and that, within certain limits, the lower the hydrogen ion concentration the greater is the swelling. It would seem, therefore, that in th...

PURPOSE Ischemia-reperfusion injury (I/R injury) is known not only to induce hypoxic and oxidative stress, but also to cause retinal degeneration in rats. Crystallins, known to inhibit the formation of reactive oxygen species, reduce apoptotic cell death. Our goal was to clarify not only the role of I/R injury-mediated crystallins, but also to evaluate the correlation of these compounds to anti...

IN previous communications (Oksala and Lehtinen, 1959; Oksala 1960a, b), I noted that vitreous haemorrhages reflected echoes on the screen of an ultrasound equipment, and that these echoes were clearer if a fresh haemorrhage was involved. I also found that old haemorrhages, on account of the destruction of the vitreous, do not always become visible in ultrasonic examinations (Oksala and Lehtine...

PURPOSE To evaluate the relationship between vascular endothelial growth factor (VEGF) and extracellular superoxide dismutase (EC-SOD) in vitreous body and serum in patients with proliferative diabetic retinopathy (PDR), and investigate the role of EC-SOD in PDR by evaluating its angiostatic effect, using an in vitro angiogenesis model. To investigate the role of EC-SOD in PDR by evaluating its...