PURPOSE In this research the effect of vitamin B1 and B6 on cyanocobalamin stability in commercial light protected parenteral formulations and upon adding stabilizing agents will be investigated and best formulation composition and proper storage condition will be introduced. METHODS In this research some additives such as co solvents and tonicity adjusters, surfactants, antioxidants and chel...

Infections caused by the methicillin-resistant Staphylococcus aureus (MRSA) are today known to be a substantial threat for global health. Emerging multi-drug resistant bacteria have created a substantial need to identify and discover new drug targets and to develop novel strategies to treat bacterial infections. A promising and so far untapped antibiotic target is the biosynthesis of vitamin B1...

Fumonisins are mycotoxins produced by Fusarium moniliforme, a common fungal contaminant of corn worldwide, 10 and F. proliferatum, a closely related species.l.Io.'9 The true incidence of F. moniliforme is difficult to determine because F. proliferatum has often been misidentified as F. moniliforme. lO,'3 Certain strains of F. proliferatum also produce moniliformin, but isolates of F. moniliform...