Idiopathic hypertrophic subaortic stenosis (IHSS) is characterized by subaortic obstruction to left ventricular (LV) outflow. However, the obstruction is variable and many patients have no resting gradient and no clinical evidence of IHSS. Although a characteristic systolic movement of the anterior mitral valve leaflet can be demonstrated echocardiographically in many patients with IHSS, this m...

BACKGROUND Left ventricular outflow tract (LVOT) obstruction is frequently responsible for symptoms in hypertrophic obstructive cardiomyopathy (HOCM). Medical therapy is often not sufficient to control these symptoms, and surgical myotomy-myomectomy is required. METHODS AND RESULTS We enrolled 33 symptomatic patients with HOCM and obstruction (>/=40 mm Hg gradient at rest or >/=60 mm Hg dobut...

Right and left heart catheterization, including selective cineangiocardiography, was performed in 20 of the 33 patients examined in a large Negro family. Fifteen had features compatible with the diagnosis of idiopathic hypertrophic subaortic stenosis. Sudden death has not occurred in this family. Many of the patients were young and were totally unaware of the heart disease, although 11 had symp...

In this review, evidence is presented to indicate that hemodynamically significant (right ventricular volume overload) atrial septal defects (ASDs) in adults should be transcatheter occluded, irrespective of symptomatology. While surgical closure is safe and effective, device closure carries less morbidity. Several devices have been investigated over the last few decades, but at the present tim...

INTRODUCTION AND OBJECTIVES Left ventricle outflow tract obstructions in transposition of the great arteries are frequent. We report the correlations between two-dimensional echocardiographic and autopsy findings to draw attention to the usefulness of this diagnostic method in the preoperative evaluation of these anomalies. MATERIAL AND METHODS Of 73 hearts with transposition of great arterie...

The morphologic determinants of subaortic obstruction in patients with hypertrophic cardiomyopathy are not completely understood. To define the relation between left ventricular outflow tract orifice size and presence or absence of subaortic obstruction, we studied 65 patients with hypertrophic cardiomyopathy and 16 normal controls by quantitative two-dimensional echocardiography. Left ventricu...

BACKGROUND It is infeasible to occlude a doubly committed juxtaarterial ventricular septal defect (DCVSD) percutaneously. The previous perventricular device closure technique was performed through an inferior median sternotomy approach. The purpose of this study is to evaluate the feasibility, safety and efficacy of perventricular device closure of DCVSDs through a left parasternal approach. ...

It is now well established that the morphology of the ventricular septal defect associated with interrupted aortic arch is such as to compromise blood flow to the ascending aorta. Though there is some evidence that a similar mechanism may be operative in coarctation with ventricular septal defect, we are unaware of any necropsy study of this hypothesis. We therefore studied 25 hearts from the H...

The clinical and morphologic features of hypertrophic cardiomyopathy in 20 patients recognized as having cardiac disease in the first year of life are described. Fourteen of these 20 infants were initially suspected of having heart disease solely because a heart murmur was identified. However, the infants showed a variety of clinical findings, including signs of marked congestive heart failure ...