Pressure-induced cardiac enlargement was created in neonatal (21 days of age) and adult (250-275 g) rats by abdominal aortic constriction. Sham-operated and aorta-constricted neonates were studied 2, 3, 4, and 5 weeks after surgery. Left ventricular weight was elevated by approximately 50% at all times studied. Radioautography demonstrated a marked elevation in H-thymidine-labeled nuclei in car...

Pressure-induced cardiac enlargement was created in neonatal (21 days of age) and adult (250-275 g) rats by abdominal aortic constriction. Sham-operated and aorta-constricted neonates were studied 2, 3, 4, and 5 weeks after surgery. Left ventricular weight was elevated by approximately 50% at all times studied. Radioautography demonstrated a marked elevation in H-thymidine-labeled nuclei in car...

Meaningful evaluation of the heart is predicated on a sound knowledge of normal anatomy, physiology, and breed variations and adherence to principles of standardized technique and positioning to eliminate non-pathologic variables. Digital radiography has helped improve radiographic technique but appropriate animal positioning remains critical. The ribs and spine should be penetrated well enough...

Data from 30 years of follow-up of the original Framingham Study cohort of 5,070 men and women aged 30-62 years who were first examined during the period 1948-1952 and who were free of cardiovascular disease reveal that blood pressure is a strong and consistent predictor of the development of coronary heart disease, stroke, transient ischemic attack, and congestive heart failure. Other factors ...

Background. The pericardium both limits cardiac distension and accentuates ventricular interdependence. Although this effect appears minimal under normal circumstances, the pericardium markedly restricts acute cardiac enlargement. Animal studies have demonstrated gradual pericardial adaptation and expansion in chronic volume overload and cardiomegaly, but the pericardial response in humans with...

BACKGROUND The pericardium both limits cardiac distension and accentuates ventricular interdependence. Although this effect appears minimal under normal circumstances, the pericardium markedly restricts acute cardiac enlargement. Animal studies have demonstrated gradual pericardial adaptation and expansion in chronic volume overload and cardiomegaly, but the pericardial response in humans with ...

We examined the morphometric and biochemical effects of ventricular hypertrophy in male rainbow trout (Oncorhynchus mykiss) during sexual maturation. Our investigation focused on characterizing the growth of ventricular layers, on cardiomyocyte dimensions (length, cross-sectional area and cell volume) and on the activities of enzymes involved in intermediary metabolism. Relative ventricle mass ...

We studied the relationship between ventricular size and nonspecific periventricular lucency on computed tomograms (leukoaraiosis) in 192 patients with ischemic stroke. Leukoaraiosis did not occur in 21 patients less than 50 years of age; ventricular size could not be measured in an additional 29. Leukoaraiosis was graded from 0 to 4 on a semiquantitative scale; bicaudate, frontal horn, and pos...

OBJECTIVES This study investigated whether exercise-induced myocardial ischemia influences left ventricular remodeling after anterior myocardial infarction. BACKGROUND The effects of acute and recurrent ischemia on ventricular function are well established. However, to our knowledge the role of exertional ischemia in the remodeling response after infarction has not been investigated. METHOD...

BACKGROUND Despite airway pressure limitation, acute cor pulmonale persists in a minority of ARDS patients. Insufficient airway pressure limitation, hypercapnia, or both may be responsible. Because prone positioning (PP) has been shown to be a safe way to reduce airway pressure and to improve alveolar ventilation, we decided to assess its effect on right ventricular (RV) pressure overload in AR...