Despite improvements in the clinical management of aneurysmal subarachnoid haemorrhage over the last decade, delayed cerebral ischaemia (DCI) remains the single most important cause of morbidity and mortality in those patients who survive the initial bleed. The pathological mechanisms underlying DCI are still unclear and the calcium channel blocker nimodipine remains the only therapeutic interv...

SATO, S. and HASHIMOTO, K. Responses of the Canine Splenic Vascular Bed to Various Biogenic and Foreign Substances . Tohoku J. exp. Med., 1973, 110 (4), 367-375 Responses of dog splenic vascular bed to various compounds administered into the splenic artery were investigated under a constant perfusion pressure. Adrenergic drugs; epinephrine, norepinephrine and dopamine produced a marked vasocons...

The purpose of this study was to determine whether vasoactive intestinal peptide (VIP) modulates vasoconstriction elicited by phenylephrine and ANG II in vivo and, if so, to begin to elucidate the mechanisms underlying this phenomenon. Using intravital microscopy, we found that suffusion of phenylephrine and ANG II elicits significant vasoconstriction in the in situ hamster cheek pouch that is ...

This experimental study aims to test thermal response and the ability acclimatize during discomfort conditions of different age groups. Experiments were conducted in late summer with thirteen participants, including university students older workers, exposed a climate chamber temperature increasing from 22°C 28°C decreasing 16°C, at rate 3.5K/h. Participants adjusted their clothing stay thermal...

Astrocytes elicit bidirectional control of microvascular diameter in acutely isolated brain slices through vasoconstriction and vasodilation pathways that can be differentially recruited via the free Ca2+ concentration endfeet and/or metabolic status tissue. However, Ca2+-level hypothesis has not been tested using direct manipulation. To overcome this, we used Ca2+-clamp whole-cell patching per...

Vasopressors and inotropes are often administered to critically ill patients in intensive care unit for the management treatment of haemodynamic impairment, heart failure, septic cardiogenic shock, trauma among certain other diseases. In with vasopressors used induce vasoconstriction or enhance cardiac contractility. induces vasoconstriction, which causes systemic vascular resistance, leading i...

We determined whether a 3-minute period of intense cardiac sympathetic stimulation, which is known to release neuropeptide Y (NPY), elicits a sustained poststimulatory coronary vasoconstriction in anesthetized dogs that had received propranolol. We also periodically measured the cardiac chronotropic responses to test vagal stimulations; these responses served as an index of the neuronal release...

Reversible cerebral vasoconstriction syndrome (RCVS) is an under-recognised condition. It is characterised by sudden and severe headaches (of "thunderclap" type) associated with multifocal reversible narrowing of the intracranial arteries on neuroradiology. The diagnosis is often established with the resolution of headaches and vasoconstriction. We report two patients with RCVS and review the a...

Reversible cerebral vasoconstriction syndromes (RCVS) are a group of disorders that have in common an acute presentation with headache, reversible vasoconstriction of cerebral arteries, with or without neurological signs and symptoms. In contrast to primary central nervous system vasculitis, they have a relatively benign course. We describe here a patient who was diagnosed with RCVS.