The fish bulbus arteriosus (BA) smooths cardiac output by expanding during cardiac systole and rebounding during diastole, thereby providing constant perfusion of the gills downstream. Published data have demonstrated innervation of the teleost BA and shown that the tension and compliance of the BA responded to vasoactive agonists, such as epinephrine and acetylcholine, suggesting that the BA w...

cology, University of Tokyo. This series of experiments was originally designed to obtain informations on the role of chemical transmitters in the CNS. Though the essential role of adrenergic as well as cholinergic transmitters in the peripheral system is generally accepted, the role of these transmitter substances in the CNS is still obscure and requires further investigations to be elucidated...

This investigation attempts to demonstrate the mechanism by which substances that block autonomic ganglionic transmission increase the pressor and depressor activities of a variety of (irugs. Short-lived hypertension and a high degree of vascular responsiveness is induced by combining cord destruction, inactivation of the carotid sinus mechanism and nephreetomn. The increased responsiveness is ...

Using isolated dog veins, we examined whether correlations exist between the regional differences in sensitivity to drugs and their embryogenesis. Twelve different veins were dissected. In the analysis, the data obtained previously for the inferior vena cava were also included. Spiral strips were prepared and the contractile responses to cumulative application of norepinephrine (NE), 5-hydroxyt...

The local intra-arterial infusion of histamine, in doses which produce maximal increases in protein efflux, failed to increase lymph total protein concentration in canine forelimbs perfused at constant inflow with autologous blood from dogs subjected to severe hemorrhagic hypotension. Norepinephrine and isoproterenol in low concentrations were less effective in antagonizing protein efflux produ...

Cardiac ultrasound investigation of 68 prospectively studied patients with histologically proven midgut carcinoid tumors showed right heart disease in 66%. The abnormal findings included morphologic and functional aberrations of the tricuspid valve in 52% and 83%, respectively, right atrial and ventricular enlargement in 53% and 30%, and paradoxical systolic septal contractions in 19%. The pati...

The contribution of the intrapulmonary lobar veins to the increase in pulmonary vascular resistance in response to sympathetic stimulation was studied under conditions of controlled blood flow in the anesthetized dog in which vascular pressures were measured simultaneously in the perfused lobar artery, an intrapulmonary lobar vein 2-3 mm in diameter and in the left atrium. Stimulation of the st...

BACKGROUND Considering that dialysate calcium concentration is potentially a main determinant of the serum ionized calcium level and vasoconstriction is associated with the blood calcium concentration, we conducted a study to evaluate the interdialytic effects of treatment with a low calcium dialysate (LdCa, 1.25 mmol/L) on the changes in arterial compliance (AC), blood pressure (BP), biochemic...

In a search for factors contributing to the sustained blood pressure (BP) elevation in acutely volume-loaded animals, dextran dissolved in lactated Ringer's solution (20 ml/kg) was infused into 34 mongrel dogs over a period of 1 hour under pentobarbital anesthesia and changes in hemodynamic and humoral variables were monitored during its infusion and for 3 hours after its infusion. BP elevation...