THE NOTION THAT SLOWLY progressive dementia in the elderly is the result of chronic diffuse brain hypoxia is largely discredited — Alzheimer disease has nothing to do with cerebral arteriosclerosis.' Nonetheless, it is still widely believed that many elderly people are demented on a cerebrovascular basis, most often in the form of "multi-infarct dementia.' ' Such a term does not refer to the ci...

Vascular cognitive impairment defines alterations in cognition, ranging from subtle deficits to full-blown dementia, attributable to cerebrovascular causes. Often coexisting with Alzheimer's disease, mixed vascular and neurodegenerative dementia has emerged as the leading cause of age-related cognitive impairment. Central to the disease mechanism is the crucial role that cerebral blood vessels ...

Background Kidney function has been linked to cognitive function, but its relation dementia and mechanisms underlying this remains unclear. We aimed examine the association of impaired kidney with brain pathologies. Method Within Rush Memory Aging Project, 1380 dementia-free subjects (75.22% female; mean age: 79.42±7.61 years) at baseline were followed for up 22 years. Blood samples taken serum...

Vascular dementia (VaD) comprises a group of syndromes caused by vascular lesions in the brain. Cognitive impairment may follow a single cortical or lacunar infarct in a strategic area of the brain, multiple infarcts, small-vessel disease (leukoaraiosis), intracerebral hemorrhage, or any of these conditions coexisting with Alzheimer dementia (so-called mixed dementia). Depending on case mix and...

Vascular dementia is the second most common type of dementia. The subcortical ischaemic form (SIVD) frequently causes cognitive impairment and dementia in elderly people. SIVD results from small-vessel disease, which produces either arteriolar occlusion and lacunes or widespread incomplete infarction of white matter due to critical stenosis of medullary arterioles and hypoperfusion (Binswanger'...

Background Dementia risk scores could be instrumental in the implementation of multidomain lifestyle interventions for dementia prevention. However, as relatively new tools, their performance requires further validation. Given extensive overlap between factors and cardiovascular disease (CVD), usually have an important vascular component better-established become useful this context. More evide...