Enterococcus members are becoming increasingly important agents of human disease, largely because of their resistance to antimicrobial agents. Because of their resistance to penicillins and cephalosporins of several activity ranges, the acquisition of high-level resistance to aminoglycosides, and now the emergence of vancomycin resistance, these bacteria are often involved in serious superinfec...

A novel glycylcycline agent, tigecycline (GAR-936), was evaluated in vivo in the mouse model of peritonitis against three Enterococcus faecalis and four Enterococcus faecium isolates with different susceptibilities to vancomycin and tetracyclines, all of which were inhibited by </=0.125 micro g of tigecycline/ml. Using a single subcutaneous dose, tigecycline displayed a protective effect (50% p...

The total synthesis of two key analogues of vancomycin containing single-atom exchanges in the binding pocket (residue 4 amidine and thioamide) are disclosed as well as their peripherally modified (4-chlorobiphenyl)methyl (CBP) derivatives. Their assessment indicates that combined pocket amidine and CBP peripherally modified analogues exhibit a remarkable spectrum of antimicrobial activity (VSS...

INTRODUCTION Laboratory-based surveillance is an important component in the control of vancomycin resistant enterococci (VRE). METHODS The study aimed to evaluate real-time polymerase chain reaction (RT-PCR) (genes vanA-vanB) for VRE detection on 115 swabs from patients included in a surveillance program. RESULTS Sensitivity of RT-PCR was similar to primary culture (75% and 79.5%, respectiv...

The complete genome sequence of Enterococcus faecalis V583, a vancomycin-resistant clinical isolate, revealed that more than a quarter of the genome consists of probable mobile or foreign DNA. One of the predicted mobile elements is a previously unknown vanB vancomycin-resistance conjugative transposon. Three plasmids were identified, including two pheromone-sensing conjugative plasmids, one en...

Türkiye’de Van ili piyasasından toplanan tavuk eti örneklerinde Enterococcus spp. prevelansı ve antibiyotik direnliliği VanA VanB direnç genlerinin belirlenmesi amaçlandı. Çalışmada 100 adet örneği kullanıldı. Bunların 27’si (%27) pozitif bulundu. 27 örneğinden toplam 67 izolatı elde edildi. Bunlardan 53’ü (%79.10) E. faecalis, 14’ü (%20.90) ise faecium olarak tespit Antibiyotik dirençlilikleri...