Lactobacillus species dominate the microbiome in the lower genital tract of most reproductive-age women. Producing lactic acid and H2O2, lactobacilli are believed to play an important role in prevention of colonization by and growth of pathogens. However, to date, there have been no reported studies characterizing how lactobacilli interact with Chlamydia trachomatis, a leading sexually transmit...

BACKGROUND Bacterial vaginosis (BV) increases the risk of spontaneous preterm deliveries (PD) in developed countries. Its prevalence varies with ethnicity, socioeconomic conditions and gestational age. Aerobic vaginitis (AV) has also been implicated with spontaneous PD. The present study aimed to estimate the prevalence of asymptomatic BV, the accuracy of vaginal pH level to predict BV and to e...

Lactobacillus species, which dominate vaginal microbiota of healthy reproductive-age women, lower the risks of sexually transmitted infections, including the risk of human immunodeficiency virus (HIV) acquisition. The exact mechanisms of this protection remain to be understood. Here, we investigated these mechanisms in the context of human cervico-vaginal and lymphoid tissues ex vivo. We found ...

BACKGROUND This multicentre, randomised, double-blind, placebo-controlled trial was performed to determine whether the use of oral probiotic preparation (prOVag®) containing three Lactobacillus strains together with standard metronidazole treatment and also targeted antibiotic treatment (following the failure of metronidazole therapy) could reduce the recurrence rates of bacterial vaginosis (BV...

Sexual transmission of human immunodeficiency virus type 1 (HIV-1) across the cervicovaginal mucosa in women is influenced by many factors including the microbiota and the presence of underlying inflammation. It is important that potential HIV preventative agents do not alter the mucosal environment in a way that enhances HIV acquisition. We examined the impact of a "live" microbicide on the va...

BACKGROUND A Lactobacillus-dominated cervicovaginal microbiota (VMB) protects women from adverse reproductive health outcomes, but the role of L. iners in the VMB is poorly understood. Our aim was to explore the association between the cervicovaginal L. iners and L. crispatus proteomes and VMB composition. METHODS The vaginal proteomes of 50 Rwandan women at high HIV risk, grouped into four V...

CLINICAL CHEMISTRY, Vol. 27, No. 12, 1981 2071 displacement during head rotation and vaginal examinations, and amniotic fluid contamination may explain in vivo differences. Biological factors, reflecting blood and tissue fluid, might also affect the measurements, producing real differences in tissue and blood pH values. At present, because of these differences, in vivo continuous measurement of...

BACKGROUND & OBJECTIVES Bacterial vaginosis (BV) is highly prevalent among women in reproductive age group. Little information exists on routine vaginal p H measurement in women with BV. We undertook this study to assess the utility of vaginal p H determination for initial evaluation of bacterial vaginosis. METHODS In this cross-sectional study vaginal swabs were collected from women with com...

This paper work was done for the incidence and type of the vaginal cavity (VC) infections (VCIs) with referring to the role in the potential of Hydrogen (pH) changes during the infection period (IP), Taif, KSA. Normal pH of VC is (3.5-4.5) for women in reproductive-age (RA). High vaginal swabs (HVSs) were collected from healthy women in RA, which complained of suspected VCIs. Incidence of micro...