the aim of this study was to determine the monthly dtr mass load of amphetamine-type compounds in poland as well as an investigation of cyclical behaviour by using time series analysis and especially trends analysis.amphetamine, methamphetamine and mdma (ecstasy) were detected in wastewater samples collected from the main wastewater treatment plant in the city of poznan using liquid chromatogra...

Background: Bioinformatic approaches for designing vaccines have become a promising alternative to conventional methods. We herein designed a multi-epitope-based vaccine against colorectal cancer (CRC). Methods: Used peptides in the CRC vaccines were retrieved from databases of PubMed, Web of Science, Google Scholar, and Clinical trials. The adjuvants of Mycobacterial heparin-binding hemagglut...

1339. Measles and Mumps Antibody Response in Young Adults after a Third Dose of Measles-Mumps-Rubella Vaccine Amy Parker Fiebelkorn, MSN, MPH; Laura Coleman, PhD, RD; Edward Belongia, MD; Sandra Freeman, CCRC; Daphne York, CCRP; Daoling Bi, MS; Cheryl Zhang, MD* (deceased); Laurie Ngo,; Steven Rubin, PhD; Ashwin Kulkarni,; Susette Audet, BS; Judith Beeler, MD; Division of Viral Diseases, Center...

the chemical components in the decoctions of chinese herbal medicines are not always the same as those in the crude herbs because of the insolubility or instability of some compounds. in this work, a high-performance liquid chromatography (hplc) coupled with electrospray ionization (esi) tandem mass spectrometry method was developed to explore dynamic variation patterns of aconitum alkaloids in...

high performance liquid chromatography (hplc) with diode array detection (dad) and electrospray ionization tandem mass spectrometry (esi/ms/ms) was used to analyze the main components in the methanol extract of fructus aurantii (fa) and the metabolites in rat biological samples after oral administration of the methanol extract of fa. there were 31 constituents identified in the extract of fa in...

Serotype 19A strains have emerged as a cause of invasive pneumococcal disease after the introduction of the 7-valent pneumococcal conjugate vaccine (PCV7), and serotype 19A has now been included in the recent 13-valent vaccine (PCV13). Genetic analysis has revealed at least three different capsular serotype 19A subtypes, and nutritional environment-dependent variation of the 19A capsule structu...

BACKGROUND We have previously shown that vaccination with DNA encoding the encephalitogenic peptide myelin oligodendrocyte glycoprotein (MOG)(91-108) (pMOG) suppresses MOG(91-108)-induced rat Experimental Autoimmune Encephalomyelitis (EAE), a model for human Multiple Sclerosis (MS). The suppressive effect of pMOG is dependent on inclusion of CpG DNA in the plasmid backbone and is associated wit...

  In 1974, the World Health Organization (WHO) established the Expanded Program on Immunization (EPI) to ensure that all children have access to routinely recommended vaccines. Since then, global coverage with the four core vaccines (Bacille calmette guérin vaccine [for protection against tuberculosis], Diphtheria-tetanus-pertussis vaccine [DTP], Polio vaccine, and Measles vaccine) has increase...

Over 230 serovars of Leptospira interrogans have been identified; however few have been completely characterised. The aim of this study was to characterise the proteome of serovar Canicola and to compare this against the serovars of Copenhageni and Pomona. 2D-LC/MS analysis identified 1653 Leptospira proteins in serovar Canicola; 60 of these proteins were common to Copenhageni and Pomona, 16 of...

The aim of this study was to identify antigens for a vaccine or drug target to control rabbit coccidiosis. A combination of 2-dimensional electrophoresis, immunoblotting, and mass spectrometric analysis were used to identify novel antigens from the sporozoites of Eimeria stiedae. Protein spots were recognized by the sera of New Zealand rabbits infected artificially with E. stiedae. The proteins...