We show that human adenovirus inhibits RNA interference (RNAi) at late times of infection by suppressing the activity of two key enzyme systems involved, Dicer and RNA-induced silencing complex (RISC). To define the mechanisms by which adenovirus blocks RNAi, we used a panel of mutant adenoviruses defective in virus-associated (VA) RNA expression. The results show that the virus-associated RNAs...

OBJECTIVE To examine past comparisons of the costs of the Veterans Health Administration (VA) and of non-VA providers to determine lessons and data requirements for future cost comparisons, particularly those assessing VA efficiency and to determine whether VA should purchase care from non-VA providers. CONCEPTUAL FRAMEWORK Over the past two decades, researchers have tried to establish how VA...

INTRODUCTUION Symptomatic severe vertebral artery (VA) stenosis may be treated safely with stent supported angioplasty via femoral access. There is limited clinical data on transradial approach for VA angioplasty in case of peripheral artery disease. AIM To evaluate the safety and efficacy of transradial angioplasty of symptomatic VA stenosis. MATERIAL AND METHODS Fifteen patients (age 66 ±...

The distance d(va,vb) between two vertices of a simple connected graph G is the length shortest path va and vb. Vertices va,vb are considered to be resolved by vertex v if d(va,v)≠d(vb,v). An ordered set W={v1,v2,v3,…,vs}⊆V(G) said resolving for G, any va,vb∈V(G),∃vi∈W∋d(va,vi)≠d(vb,vi). representation with respect W denoted r(v|W) an s-vector(s-tuple) (d(v,v1),d(v,v2),d(v,v3),…,d(v,vs)). Using...

There are few reports describing stroke due to the acute occlusion of the vertebral artery (VA) origin successfully treated by endovascularily. The authors report a case of 78-year-old man suffering from stroke owing to acute VA origin occlusion associated with contralateral hypoplastic VA leading to basilar artery (BA) thrombosis. Cerebral angiography demonstrated that the right VA was occlude...

OBJECTIVE To determine the baseline predictors of visual acuity (VA) outcomes 1 year after treatment with ranibizumab or bevacizumab for neovascular age-related macular degeneration (AMD). DESIGN Cohort study within the Comparison of Age-related Macular Degeneration Treatments Trials (CATT). PARTICIPANTS A total of 1105 participants with neovascular AMD, baseline VA 20/25 to 20/320, and VA ...

352. Clinical and molecular characteristics of NDM-1 harboring MultiDrug Resistant Gram Negative Bacteria at Carilion Medical Center Ekta Bansal, MD; Thomas Kerkering, MD; Charles Schleupner, MD; Ritesh Kohli, MD; Anthony Baffoe, MBChB; Endang Purwantini, PhD; Biswarup Mukhopadhyay, PhD; Jayasimha Rao, PhD; Virginia Tech Carilion School of Medicine, Roanoke, VA; Infectious Diseases, Carilion Cl...

Hailing Yang, Graduate Student, Virginia Tech, Blacksburg, VA Wei Zhang, Research Scientist, Advance and Applied Polymer Processing Institute, Institute of Advance Learning and Research, Danville, VA Ronald D, Moffitt, Director and Research Associate Professor, Advance and Applied Polymer Processing Institute, Institute of Advance Learning and Research, Danville, VA Thomas C. Ward, Professor, V...

Myosin-Va is an actin-based processive motor that conveys intracellular cargoes. Synaptic vesicles are one of the most important cargoes for myosin-Va, but the role of mammalian myosin-Va in secretion is less clear than for its yeast homologue, Myo2p. In the current studies, we show that myosin-Va on synaptic vesicles interacts with syntaxin-1A, a t-SNARE involved in exocytosis, at or above 0.3...

To investigate the role that myosin Va plays in axonal transport of organelles, myosin Va-associated organelle movements were monitored in living neurons using microinjected fluorescently labeled antibodies to myosin Va or expression of a green fluorescent protein-myosin Va tail construct. Myosin Va-associated organelles made rapid bi-directional movements in both normal and dilute-lethal (myos...