نتایج جستجو برای: uveal melanoma

تعداد نتایج: 54264  

Journal: :Archives of ophthalmology 2012
Alok S Bansal Carlos G Bianciotto Joseph I Maguire Carl D Regillo Jerry A Shields Carol L Shields

OBJECTIVE To determine the long-term safety of pars plana vitrectomy (PPV) in eyes with plaque-irradiated posterior uveal melanoma. METHODS In this retrospective case series, patients with plaque-irradiated posterior uveal melanoma subsequently underwent PPV for vitreous hemorrhage. The main outcome measures are the rates of intraocular melanoma dissemination, extrascleral extension of melano...

Journal: :Journal of epidemiology and community health 2001
C Huerta L A Rodríguez

Intraocular melanomas are the most common primary ocular malignancy in white people accounting for approximately 70% of all eye malignancies in adults. Most ocular melanomas arise from uveal melanocytes distributed throughout the stroma of the choroid, only 4%–10% of uveal melanomas originate in the iris. Data on the incidence of intraocular melanoma are limited with estimates of incidence rate...

2017
Paolo Fagone Rosario Caltabiano Andrea Russo Gabriella Lupo Carmelina Daniela Anfuso Maria Sofia Basile Antonio Longo Ferdinando Nicoletti Rocco De Pasquale Massimo Libra Michele Reibaldi

Melanoma of the uveal tract accounts for approximately 5% of all melanomas and represents the most common primary intraocular malignancy. Despite improvements in diagnosis and more effective local therapies for primary cancer, the rate of metastatic death has not changed in the past forty years. In the present study, we made use of bioinformatics to analyze the data obtained from three public a...

2017
Haiming Xu Jingwen Gong Hui Liu

The plasmacytoma variant translocation 1 gene (PVT1) plays an oncogenic role in the initiation and progression of multiple cancers. In this study, by using deep-sequencing data and follow-up data in the Cancer Genome Atlas-Uveal melanomas (TCGA-UVM), we assessed the association between the expression of PVT1 and clinicopathological characteristics of patients with uveal melanoma, the mechanism ...

Journal: :Annals of oncology : official journal of the European Society for Medical Oncology 2013
M Maio R Danielli V Chiarion-Sileni J Pigozzo G Parmiani R Ridolfi F De Rosa M Del Vecchio L Di Guardo P Queirolo V Picasso P Marchetti F De Galitiis M Mandalà M Guida E Simeone P A Ascierto

BACKGROUND Patients with advanced uveal melanoma have a poor prognosis and limited treatment options. Ipilimumab is approved for pre-treated adult patients with advanced melanoma. However, because previous clinical trials with ipilimumab have excluded patients with uveal melanoma, data in this patient population are limited. PATIENTS AND METHODS Pre-treated patients with advanced uveal melano...

Journal: :The British journal of ophthalmology 1995
D H Char T Miller

AIMS/BACKGROUND This study was performed to ascertain the diagnostic accuracy rate of non-invasive tests in patients with presumed uveal melanomas scheduled to be treated with either irradiation or cyclochoroidectomy. METHODS One hundred consecutive patients who had non-invasive tests followed by fine needle aspiration biopsy (FNAB) as prior alternative treatment were analysed retrospectively...

2013
Andrea Treszl Zita Steiber Andrew V. Schally Norman L Block Balazs Dezso Gabor Olah Bernadett Rozsa Klara Fodor Armin Buglyo Janos Gardi Andras Berta Gabor Halmos

Uveal melanoma is the most common primary intraocular malignancy in adults, with a very high mortality rate due to frequent liver metastases. Consequently, the therapy of uveal melanoma remains a major clinical challenge and new treatment approaches are needed. For improving diagnosis and designing a rational and effective therapy, it is essential to elucidate molecular characteristics of this ...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2011
Mrinali Patel Elizabeth Smyth Paul B Chapman Jedd D Wolchok Gary K Schwartz David H Abramson Richard D Carvajal

Uveal melanoma represents the most common primary intraocular malignancy in adults. Although uveal and cutaneous melanomas both arise from melanocytes, uveal melanoma is clinically and biologically distinct from its more common cutaneous counterpart. Metastasis occurs frequently in this disease, and once distant spread occurs, outcomes are poor. No effective systemic therapies are currently ava...

Journal: :Archives of ophthalmology 2001
A G Scholes S Hagan P Hiscott B E Damato I Grierson

OBJECTIVE To determine whether expression of the epidermal growth factor receptor (EGFR) is of prognostic value in uveal melanoma. METHODS Thirty consecutive patients treated for primary posterior uveal melanoma by enucleation or local resection were studied. Tumors were examined for EGFR and CD68 expression by immunohistochemistry on formalin-fixed, paraffin-embedded sections. Extracted DNA ...

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