Langerhans cells (LCs) are the predominant antigen-presenting cells distributed in the mucosa of various organs with high antigenic exposure. They capture antigens, process and present them to the T lymphocytes. LCs are known to be present in the human female reproductive tract. Very few studies have demonstrated the presence of LCs in human uterine tubes. The aim of the present study was to de...

Introduction. Invasive mole, a form of gestational trophoblastic neoplasia (GTN), is defined as penetration molar tissue into the myometrium and/or presence extra-uterine metastases. An invasive mole arising from complete hydatidiform more common than an partial mole. Dilatation and uterine evacuation curettage (D&E/C) first step in managing pregnancy. Uterine perforation most serious compl...

Uterine leiomyosarcoma (LMS) develops more often in the muscle tissue layer of the uterine body than in the uterine cervix. The development of gynecologic tumors is often correlated with female hormone secretion; however, the development of uterine LMS is not substantially correlated with hormonal conditions, and the risk factors are not yet known. Importantly, a diagnostic-biomarker, which dis...

size of a seven months' pregnancy (Fig. 1). It consists of one large cavity, containing more than two pints of blood-stained serous fluid. The walls of this large blood-cyst show the structure of a uterine fibroid; the cavity is lined in parts with soft, yellowish-white breaking-down tissue showing the changes of perithelioma (Fig. 2). The uterine cavity extends round one-third of the tumour, h...

The data described in this article is the subject of an article in the American Journal of Physiology: Cell Physiology, titled "The Human Uterine Smooth Muscle S-nitrosoproteome Fingerprint in Pregnancy, Labor, and Preterm Labor" (doi:10.1152/ajpcell.00198.2013) (Ulrich et al., 2013) [1]. The data described is a large scale mass spectrometry data set that defines the human uterine smooth muscle...

Uterine lipoleiomyomas are rare benign lesions composed of mature adipose tissue and smooth muscle cells. Uterine lipoleiomyomas are mostly found in the fundus or cervix and extremely rare in the broad ligament. Preoperative diagnosis of lipoleiomyoma of the broad ligament is very difficult due to its similarity to ovarian tumor. We report a 56-year-old menopausal woman with huge lipoleiomyoma ...

The present study tested the hypothesis that the pregnancy-associated increase in endothelium-dependent relaxation of the uterine artery was mediated primarily by an increase in nitric oxide (NO) release, resulting in a reduction in smooth muscle intracellular Ca(2+) concentration ([Ca(2+)](i)). Uterine arteries obtained from nonpregnant and near-term (140 days gestation) pregnant sheep were us...

IGF-I is a critical regulator of uterine growth, and locally produced uterine IGF-I could mediate the effects of 17beta-E2 on growth and cellular proliferation. We used IGF-I knockout (KO) mice and tissue grafting to determine the roles of local and systemic IGF-I in uterine growth and E2 responsiveness. Uteri from adult KO mice and neonatal and adult wild-type (WT) mice were grown under the re...

A single gene encodes the key enzyme for estrogen biosynthesis termed aromatase, inhibition of which effectively eliminates estrogen production. Aromatase inhibitors successfully treat breast cancer and endometriosis, whereas their roles in endometrial cancer, uterine fibroids, and aromatase excess syndrome are less clear. Ovary, testis, adipose tissue, skin, hypothalamus, and placenta express ...

endometriosis is defined as the presence of functioning endometrial tissue outside the uterine cavity. endometriosis can sometimes occur in a previous surgical scar. scar endometriosis is rare and difficult to diagnose. it mostly follows obstetrical and gynecological surgeries. this condition is often confused with other surgical conditions. we are reporting one case of scar endometriosis invol...