Nitric oxide relaxes myometrium in a cGMP-independent manner. Although cGMP activates its cognate kinase, this is not required for the inhibitory effect of nitric oxide. Thus, nitric oxide-mediated cGMP elevation does not enjoy the same set of substrates as it does in other smooth muscles. To further understand the regulation of relaxation of uterine muscle by cGMP, we have studied the actions ...

Normal pregnancy is associated with reductions in total vascular resistance and arterial pressure possibly due to enhanced endothelium-dependent vascular relaxation and decreased vascular reactivity to vasoconstrictor agonists. These beneficial hemodynamic and vascular changes do not occur in women who develop preeclampsia; instead, severe increases in vascular resistance and arterial pressure ...

Introduction: Current pelvic MRI protocols rely predominantly on anatomic sequences for evaluation of the uterus. Functional MR sequences may provide imaging biomarkers with added value for the detection, characterization, and follow-up of treatment response of benign and malignant uterine pathology. Examples of functional MR parameters that have been explored within the uterus in separate stud...

OBJECTIVES With significant vaginal prolapse, it is often difficult to differentiate among cystocele, enterocele, and high rectocele by physical examination alone. Our group has previously demonstrated the utility of magnetic resonance imaging (MRI) for evaluating pelvic prolapse. We describe a simple objective grading system for quantifying pelvic floor relaxation and prolapse. METHODS One h...

To the Editor:—I read with interest the study about the effect of a-2 adrenergic agonists on the spinal pial microcirculation in dogs. Using an in vivo technique, the authors observed a significant constriction of both pial arterioles and venules after topical application of clonidine or dexmedetomidine. They suggested that a-2 agonists might be superior to epinephrine or phenylephrine as local...

BACKGROUND At term, cervical ripening in coordination with uterine contractions becomes a prerequisite for a normal vaginal delivery. Currently, cervical ripening is considered to occur independently from uterine contractions. Many evidences suggest that cervical ripening resembles an inflammatory process. Comparatively little attention has been paid to the increased flexibility of the pelvic s...

Background: Uterine bleeding is an important side effect of cesarean section which is due to non contractile uterine. The aim of this study was to compare the effect of 10% dextrose (IV infusion) and 40 IU/L oxytocin (IV infusion) on uterine contraction. Materials and Methods: This research was a double-blinded randomized clinical trial (RCT) study. 120 women were equally included in the tw...

the molecular weight distribution of 4 commercial isotactic polypropylene (ipp) samples was estimated using rheological data. the dynamic moduli data, obtained from rheological measurements in linear viscoelastic region was used for calculation of relaxation time spectrum, h(τ) and then shear relaxation modulus, g(t). finally, applying thimm kernel function and relaxation modulus data in genera...

background: uterine arteriovenous malformation is a rare but potential life-threatening source of bleeding. a high index of suspicion and accurate diagnosis of the condition in a timely manor are essential because instrumentation that is often used for other sources of uterine bleeding can be lead to massive hemorrhage. case: we describe here a case of uterine arteriovenous malformation. a 32-y...