Sphingosine 1-phosphate (S1P), a bioactive sphingolipid involved in diverse biological processes, is generated by sphingosine kinase (SphK) and acts via intracellular and/or extracellular mechanisms. We used biochemical, pharmacological, and physiological approaches to investigate in rat myometrium the contractile effect of exogenous S1P and the possible contribution of SphK in endothelin-1 (ET...

The present study examined the role of cGMP in the regulation of alpha(1)-adrenoceptor-mediated pharmacomechanical coupling in the uterine artery of near-term pregnant sheep. The cell-permeable cGMP analog 8-bromo-cGMP produced a dose-dependent relaxation of the uterine artery and shifted norepinephrine (NE) dose-response curve to the right with a decreased maximal contraction. Accordingly, 8-b...

Both the uterus and bladder contain cannabinoid (CB) receptors whose functions are poorly understood. Here, in urethane-anesthetized female rats in metestrus, we simultaneously compared the effects of close-arterial injections of the cannabinoid receptor agonist WIN 55,212-2 (WIN2) on uterine contractions (amplitude and rate) and micturition thresholds (MT) assessed by cystometry. Five doses of...

BACKGROUND Management of preterm labor by tocolysis remains an unmet medical need. Prostaglandins play a major role in regulation of uterine activity and in molecular mechanisms of human labor and parturition. There is some circumstantial evidence that prostaglandin F2alpha by action through the prostaglandin receptor subtype FP is effective in key events during labor uterine contraction, ruptu...

Trauma during pregnancy is remarkably common, and is greatly underestimated in terms of its contribution to both maternal and perinatal morbidity and mortality. Motor vehicle crashes, falls, assaults, including domestic violence, are all important mechanisms of injury, and clinical algorithms have been developed to manage the injured pregnant women. Focus on recognition and management of the mo...

Preterm delivery is currently a global concern of maternal and child health, which directly affects infants’ early morbidity, even death in several severe cases. Therefore, it particularly important to effectively monitor the uterine contraction perinatal pregnant women, make effective prediction timely treatment for possibility preterm delivery. Electromyography (EHG) signal, an measurement pr...

Uterine contractions were monitored in 54 patients in whom severe abruptio placentae had caused intra-uterine death of the fetus. The frequency at the beginning of monitoring ranged from 2 to 14 contractions in 10 minutes, with a mean of 8,4. Only 4 patients had 4 or fewer contractions in the first 10 minutes of monitoring. No change in contraction frequency was observed during the course of la...

Copyright © 2012. Korean Society of Obstetrics and Gynecology Curettage has been the method of choice for treatment of spontaneous abortion from the past. However, such a surgical treatment method can induce abortion-related complications such as bleeding, infection, and uterine damage and perforation, and increase maternal morbidity, and even in some cases it has been reported to be related to...

Uterine contraction-induced pain (UCP) represents a common and severe form of visceral pain. Nerve fibers that innervate uterine tissue express the transient receptor potential vanilloid channel 1 (TRPV1), which has been shown to be involved in the perception of UCP. The phosphoinositide-interacting regulator of TRP (Pirt) may act as a regulatory subunit of TRPV1. The intraperitoneal injection ...

The research is devoted to the study of contractility myometrium in cows using a rubber balloon and piezoelectric pressure sensor. It has been established that with an increase time after calving, number uterine contractions, values intrauterine contraction index gradually decrease. have decisive influence on value index. most convenient method for studying contractile function uterus can be co...